Evidence map›Paper›PMID 39830992›Full record

ArticleJAAD international2025

NRAS tumor mutations are associated with reduced odds of dermatologic adverse events in patients with metastatic melanoma receiving immune checkpoint inhibitors.

Michael S Chang, Jordan T Said, Elliot H Akama-Garren, Nicole Trepanowski, Ai-Tram N Bui, Anita Giobbie-Hurder, Nicole R LeBoeuf, Rebecca I Hartman

Abstract read
In one paragraph

Article in JAAD international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael S ChangHarvard Medical School, Boston, Massachusetts.
Jordan T SaidHarvard Medical School, Boston, Massachusetts.
Elliot H Akama-GarrenHarvard Medical School, Boston, Massachusetts.
Nicole TrepanowskiDepartment of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts.
Ai-Tram N BuiHarvard Medical School, Boston, Massachusetts.
Anita Giobbie-HurderDivision of Biostatistics, Department of Data Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts.
Nicole R LeBoeufHarvard Medical School, Boston, Massachusetts.
Rebecca I HartmanHarvard Medical School, Boston, Massachusetts.

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
TRAINING IN TRANSPLANTATION BIOLOGYT32AI007529 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 1998 to 2024
$6.4M
Follicular helper T cells as drivers of epitope spreadingF30AI160909 · NIAID · HARVARD MEDICAL SCHOOL · PI AKAMA-GARREN, ELLIOT HIDEKI · 2021 to 2023
$125k
NIAID NIH HHS F30 AI160909NIAID NIH HHS T32 AI007529NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

anti-PD-1anti-PDL-1atezolizumabavelumabcemiplimabdAEdurvalumabICIipilimumabmelanomamutationnivolumabNRASpembrolizumab

Identifiers

PMID39830992
PMCPMC11742302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.