Evidence map›Paper›PMID 39830896›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2024

scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria.

Collins M Morang'a, Riley S Drake, Vincent N Miao, Nancy K Nyakoe, Dominic S Y Amuzu, Vincent Appiah, Yaw Aniweh, Yaw Bediako, Saikou Y Bah, Alex K Shalek and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Collins M Morang'aWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
Riley S DrakeProgram in Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Boston, MA, United States.
Vincent N MiaoProgram in Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Boston, MA, United States.
Nancy K NyakoeWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
Dominic S Y AmuzuWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
Vincent AppiahWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
Yaw AniwehWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
Yaw BediakoWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
Saikou Y BahSchool of Infection and Immunity, Medical, Veterinary, and Life Sciences (MVLS), University of Glasgow, Glasgow, United Kingdom.
Alex K ShalekProgram in Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Boston, MA, United States.
Gordon A AwandareWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
Thomas D OttoSchool of Infection and Immunity, Medical, Veterinary, and Life Sciences (MVLS), University of Glasgow, Glasgow, United Kingdom.
Lucas Amenga-EtegoWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.

Funding

Wellcome TrustWellcome Trust 104111/Z/14/AWellcome Trust 104111/Z/14/ZWellcome Trust 107755/Z/15/Z
6 · The paper itself

Abstract

Malaria causes significant morbidity and mortality worldwide, disproportionately impacting sub-Saharan Africa. Disease phenotypes associated with

Indexed as

InterferonsMalaria, FalciparumMonocytesNF-kappa BTumor Necrosis Factor-alphaAdolescentChildChild, PreschoolFemaleHumansInfantMalePlasmodium falciparumRNA-SeqSignal TransductionSingle-Cell Gene Expression AnalysisInterferonsNF-kappa BTumor Necrosis Factor-alphacell-cell interactionsimmune responsesmonocytesPlasmodium falciparumscRNA-SequencingTNF-α signaling via NFκBuncomplicated malaria

Identifiers

PMID39830896
PMCPMC11738629

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.