A Topical Formulation Containing

Uma Santhanam, Jaime Emmetsberger, Gregory Nole, Arisa Ortiz, Michael Gold, Claude Saliou

Abstract read

In one paragraph

Article in The Journal of clinical and aesthetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

A Topical Formulation ContainingThe Journal of clinical and aesthetic dermatology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Uma SanthanamDrs. Santhanam and Emmetsberger are with La Mer, Max Huber Research Labs in Melville, New York and The Estée Lauder Companies in Melville, New York.

Jaime EmmetsbergerDrs. Santhanam and Emmetsberger are with La Mer, Max Huber Research Labs in Melville, New York and The Estée Lauder Companies in Melville, New York.

Gregory NoleMr. Nole is with Greg Nole Consulting and Technical Service LCC in Cheshire, Connecticut.

Arisa OrtizDr. Ortiz is with the Department of Dermatology at the University of California in San Diego, California.

Michael GoldDr. Gold is with Gold Skin Care Center, Tennessee Clinical Research Center in Nashville, Tennessee.

Claude SaliouDr. Saliou is with The Estée Lauder Companies in Melville, New York.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The primary objective of these studies was to evaluate the potential of a serum containing Macrocystis pyrifera ferment (MPF-Serum) to both strengthen the barrier of intact skin and enhance barrier recovery after a non-ablative laser procedure or glycolic acid chemical peel. Methods: Two whole-face clinical trials and three split-face, randomized, controlled clinical trials were conducted in women aged 31 to 65 years. The effect of MPF-Serum on barrier integrity and strength was assessed by transepidermal water loss measurement before and after controlled tape-stripping experiments and in-clinic 70% glycolic acid peel and non-ablative laser procedures. Results: Application of MPF-Serum twice daily for eight weeks on intact skin significantly increased mean moisturization by 16 percent and improved barrier integrity by 11 percent ( Limitations: These clinical studies were conducted at a limited number of sites, with limited sample sizes and populations. Conclusion: This topical MPF-Serum effectively improves barrier integrity and strength and helps to reduce recovery time from dermatologic procedures such as glycolic acid peel and laser treatments.

Indexed as

glycolic acidMacrocystis pyriferaMacrocystis pyrifera fermentnon-ablative laserSkin barriertopical serumtransepidermal water loss

Identifiers

PMID39830829

PMCPMC11741175

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.