ArticleTranslational lung cancer research2024
Quantitative evaluation of accumulated and planned dose deviations in patients undergoing gated and non-gated lung stereotactic body radiation therapy patients: a retrospective analysis.
Article in Translational lung cancer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Stereotactic body radiation therapy (SBRT) is crucial for treating early-stage inoperable non-small cell lung cancer (NSCLC) due to its precision and high-dose delivery. This study aimed to investigate the dosimetric deviations in gated (GR) versus non-gated radiotherapy (NGR), analyzing the impact of tumor location, target volume, and tumor motion range on dose distribution accuracy. Methods: Sixty patients treated with either gated (n=30) or non-gated (n=30) SBRT for early-stage NSCLC were retrospectively analyzed. The planned dose distributions were determined using four-dimensional computed tomography simulations to account for breathing motion, while the actual dose delivered was determined by accumulating each fractional dose with synthetic computed tomography (sCT) methods. The deviations between the planned and actual accumulated doses were statistically analyzed for both groups. The effects of tumor location and volume on dose distribution were also assessed. Results: Gated SBRT showed significantly higher dosimetric precision with median relative changes in the minimum dose within the ITV (ITV_D Conclusions: Gated SBRT affords dosimetric accuracy compared to non-gated SBRT, and thus could improve the therapeutic outcomes of NSCLC patients. These results should advocate for the preferential use of gated SBRT in cases requiring precise dose delivery due to large respiratory motion or small target volumes.
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