ArticleACS environmental Au2025
Haloacetonitriles Induce Structure-Related Cellular Toxicity Through Distinct Proteome Thiol Reaction Mechanisms.
Article in ACS environmental Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Haloacetonitriles (HANs) are a class of toxic drinking water disinfection byproducts (DBPs). However, the toxicity mechanisms of HANs remain unclear. We herein investigated the structure-related in vitro toxicity of 6 representative HANs by utilizing complementary bioanalytical approaches. Dibromoacetonitrile (DBAN) displayed strong cytotoxicity and Nrf2 oxidative stress responses, followed by monohalogenated HANs (monoHANs) while other polyhalogenated HANs (polyHANs) exhibited little toxicity. Activity based protein profiling (ABPP) revealed that toxic HANs adduct to human proteome thiols, supporting thiol reactivity as the primary toxicity mechanism for HANs. By using glutathione (GSH) as a thiol surrogate, monoHANs reacted with GSH via S
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