ReviewDrug and alcohol dependence reports2025
Association of substance use with suicide mortality: An updated systematic review and meta-analysis.
Review in Drug and alcohol dependence reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Pioglitazone for the treatment of alcohol use disorder: A randomized controlled trial.Addiction (Abingdon, England) · 2026Trial
- Suicidal thoughts and behaviours in Cape Town: A cross-sectional study of prevalence and social, contextual, and clinical correlates.SSM. Mental health · 2026Article
- Self-stigma and suicide cognitions in substance use disorder: the mediating role of psychological distress and the moderating role of social support.BMC psychiatry · 2026Article
- Trends in Associations Between Substance Use and Suicidality and Patterns of Current Substance Use in U.S. Adolescents: A Repeated Cross-Sectional Study.American journal of preventive medicine · 2026Article
- Applying the reinforcer pathology model to alcohol use and suicide risk: An initial test.Journal of the experimental analysis of behavior · 2026Article
- Trauma and suicidality in adolescents with substance use disorders.Child and adolescent psychiatry and mental health · 2026Article
- Collectivism and Suicide Risk: Reinterpreting Interpersonal Theory Constructs in Southern Belize.Suicide & life-threatening behavior · 2026Article
- Epigenetic Evidence Implies Disturbed Proteostasis and Potentially Protein Aggregation in Suicidality.Biomolecules · 2026Review
- Suicidal thoughts and behaviours in Cape Town: a cross-sectional study of prevalence, social, contextual, and clinical correlates.medRxiv : the preprint server for health sciences · 2026Article
- Cross-Sectional Examination of Hospital Visits in the Year Prior to Suicide Death in Illinois.The western journal of emergency medicine · 2026Article
- Rural-Urban Suicide Mortality Disparities in High-Burden U.S. States: An Intersectional Analysis.Healthcare (Basel, Switzerland) · 2026Article
- The trend of self-harm incidence rates among adolescents in low- and lower-middle-income countries and its associated contextual factors.Global mental health (Cambridge, England) · 2026Article
- The impact of COVID-19 and public health measures on homicide and suicide trends in Botswana using an interrupted time series analysis.Injury epidemiology · 2025Article
- Suicide, Psychoactive Substances, and Homelessness: A Scoping Review.Brain sciences · 2025Review
- Prevalence and predictors of substance use as a factor in suicide in the USA, 2015-2020: a repeated cross-sectional analysis.BMJ public health · 2025Article
- Is suicide risk 100-fold higher in people with HIV? A critical appraisal of a meta-analysis.General psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Background: Rates of suicide mortality and substance use have increased globally. We updated and extended existing systematic reviews of the association between substance use and suicide. Methods: This systematic review and meta-analysis explored the association between substance use and suicide mortality in peer reviewed, longitudinal cohort studies published from 2003 through 2024. Risk of bias was assessed using the Newcastle-Ottawa Scale. Pooled data were analyzed using a quality effects model. Meta-regression was used to assess the effect of moderation by study quality. Asymmetry in funnel plots and Doi plots were used to detect reporting bias. Findings: The analysis involved 47 studies from 12 countries. Substance misuse (SMR: 5.58, 95 % CI: 3.63-8.57, I Conclusions: This meta-analysis highlights that substance misuse remains a significant suicide risk factor. It underscores the need for universal and targeted prevention and equitable access to effective interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.