Evidence map›Paper›PMID 39830571›Full record

ArticleCureus2024

A Case of Eltrombopag-Induced Thrombotic Microangiopathy Initiating Hemodialysis.

Haruka Fukuda, Mineaki Kitamura, Sayaka Sugiyama, Atsushi Sawase, Hiroshi Yamashita, Hideki Tsushima, Junji Irie, Eisuke Katafuchi, Toshiyuki Nakayama, Hiroshi Mukae and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haruka FukudaNephrology, Nagasaki Harbor Medical Center, Nagasaki, JPN.
Mineaki KitamuraNephrology, Nagasaki University Hospital, Nagasaki, JPN.
Sayaka SugiyamaNephrology, Nagasaki Harbor Medical Center, Nagasaki, JPN.
Atsushi SawaseNephrology, Nagasaki Harbor Medical Center, Nagasaki, JPN.
Hiroshi YamashitaNephrology, Nagasaki Harbor Medical Center, Nagasaki, JPN.
Hideki TsushimaHematology, Nagasaki Harbor Medical Center, Nagasaki, JPN.
Junji IriePathology, Nagasaki Harbor Medical Center, Nagasaki, JPN.
Eisuke KatafuchiPathology, University of Occupational and Environmental Health, Kitakyushu, JPN.
Toshiyuki NakayamaPathology, University of Occupational and Environmental Health, Kitakyushu, JPN.
Hiroshi MukaeRespiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JPN.
Tomoya NishinoNephrology, Nagasaki University Hospital, Nagasaki, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thrombopoietin receptor agonists are used in addition to steroids for idiopathic thrombocytopenic purpura. A 55-year-old male with idiopathic thrombocytopenic purpura, treated with eltrombopag, developed a rapid decline in renal function following the increase in eltrombopag dose. Renal biopsy showed glomerular endothelial disorder and platelet thrombus, which suggested eltrombopag-induced renal-limited thrombotic microangiopathy. He was treated with steroids; however, his renal function did not improve, and hemodialysis was initiated. During the treatment, acute myocardial infarction and arteriovenous fistula obstruction occurred. After that, he was subsequently diagnosed with antiphospholipid antibody syndrome. Eltrombopag can cause thrombotic microangiopathy and, in some cases, result in renal failure. Patients with idiopathic thrombocytopenic purpura coexisted with antiphospholipid antibody syndrome are at increased risk of thrombosis with thrombopoietin agonists and require careful follow-up.

Indexed as

antiphospholipid syndromeeltrombopagend-stage renal disease (esrd)idiopathic thrombocytopenic purpurathrombotic microangiopathy

Identifiers

PMID39830571
PMCPMC11740830

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.