ArticlePlastic and reconstructive surgery. Global open2025
Novel Frostbite Cooling Device for Real-time Assessment and Prevention of Chemotherapy-induced Peripheral Neuropathy.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Impact of an Ophthalmic Cooling Device on Corneal Immune and Sensory Nerve Features in Chronic Ocular Surface Pain: A Prospective, Feasibility Study.Ophthalmology and therapy · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chemotherapy-induced peripheral neuropathy (CIPN) affects 29%-68% of patients undergoing anticancer treatments within the first month. Traditional cryotherapy methods, such as frozen gloves, can pose risks. This study evaluates the cool-water electric circulation seat (CECS), which maintains a constant 15°C, as a safer alternative. Methods: In this prospective study, 21 healthy Japanese adults underwent 2.5 hours of hand cooling at 15°C, reflecting the standard duration of taxane anticancer drug administration. Microcirculation was evaluated using videocapillaroscopy before and after cooling. Results: Results showed significant reductions in blood vessel area and altered red blood cell movement postcooling. Finger temperature and vascular area decreased significantly ( Conclusions: The CECS effectively provides secure cooling, offering a promising approach for CIPN prevention without frostbite risk. These findings highlight the potential advantages of CECS in sustained cooling therapy for CIPN prevention.
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Registered trials
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