ArticleNational science review2025
A soft, ultra-tough and multifunctional artificial muscle for volumetric muscle loss treatment.
Article in National science review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Gentle yet powerful artificial muscles enabled by hierarchical structure engineering.Nature communications · 2026Article
- Pre-priming cell sheet therapy enabled by dynamic wrinkled electroactive substrate for muscle reconstruction.Bioactive materials · 2026Article
- Gelatin-Based Multifunctional Hydrogels for Sports Injury Repair: Musculoskeletal and Nervous System Perspectives.Gels (Basel, Switzerland) · 2026Review
- Body-responsive shape-memory polymers for biomedical applications.Bioactive materials · 2026Review
- Filament sensing tension: A bionic artificial tendon for self-force-regulated artificial muscle-driven wearable robotics.Science advances · 2026Article
- TGFβ1-loaded extracellular matrix hydrogels promote skeletal muscle stem cell regeneration via m6A-mediated integrin-ERK signaling.Journal of translational medicine · 2026Article
- Muscle loss treatment by muscle-inspired shape-memory polymers.National science review · 2025Article
- Rapid neuralized and vascularized osteogenesis in infected bone defect using biomimetic biomineralized and antibacterial hydrogels.Frontiers in bioengineering and biotechnology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The escalating prevalence of skeletal muscle disorders highlights the critical need for innovative treatments for severe injuries such as volumetric muscle loss. Traditional treatments, such as autologous transplants, are constrained by limited availability and current scaffolds often fail to meet complex clinical needs. This study introduces a new approach to volumetric muscle loss treatment by using a shape-memory polymer (SMP) based on block copolymers of perfluoropolyether and polycaprolactone diol. This SMP mimics the biomechanical properties of natural muscle, exhibiting a low elastic modulus (2-6 MPa), high tensile strength (72.67 ± 3.19 MPa), exceptional toughness (742.02 ± 23.98 MJ m
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.