ArticlemedRxiv : the preprint server for health sciences2025
Evaluating the association of
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Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
41 authors.
Alaina DurantVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 3319 West End Ave, Rm 819, Nashville, TN 37203, USA.
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195-6420, USA.ORCID 0000-0003-2522-2884
Michael L LeeDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195-6420, USA.
Seo-Eun ChoiDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195-6420, USA.
Phoebe ScollardDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195-6420, USA.ORCID 0000-0002-4094-938X
Brandon S KlinedinstDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195-6420, USA.ORCID 0000-0003-2697-1852
Emily H TrittschuhDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195-6560, USA.
Jesse MezDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston University Medical Center, 85 East Concord Street, 1st floor, Boston, MA 02118, USA.ORCID 0000-0003-1438-5442
Lindsay A FarrerDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston University Medical Center, 85 East Concord Street, 1st floor, Boston, MA 02118, USA.ORCID 0000-0001-5533-4225
Katherine A GiffordVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 3319 West End Ave, Rm 819, Nashville, TN 37203, USA.ORCID 0000-0001-6232-9408
Carlos CruchagaDepartment of Psychiatry, Washington University in St. Louis, 4444 Forest Park Avenue, St. Louis, MO 63108, USA.ORCID 0000-0002-0276-2899
Jason HassenstabDepartment of Neurology and Department Psychological & Brain Sciences, Washington University in St Louis, 1 Brookings Drive, St. Louis, MO 63130, USA.ORCID 0000-0002-7802-3371
Adam C NajDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA.ORCID 0000-0002-9621-2942
Li-San WangPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 3400 Spruce St., Philadelphia, PA 19104-4238, USA.ORCID 0000-0002-3684-0031
Sterling C JohnsonAlzheimer's Disease Research Center, University of Wisconsin-Madison, School of Medicine and Public Health, 600 Highland Ave J5/1 Mezzanine, Madison, WI 53792, USA.ORCID 0000-0002-8501-545X
Corinne D EngelmanAlzheimer's Disease Research Center, University of Wisconsin-Madison, School of Medicine and Public Health, 600 Highland Ave J5/1 Mezzanine, Madison, WI 53792, USA.ORCID 0000-0003-4750-5607
Walter A KukullDepartment of Epidemiology, School of Public Health, University of Washington, 3980 15 Ave NE, Seattle, WA 98195, USA.ORCID 0000-0001-8761-9014
C Dirk KeeneDepartment of Laboratory Medicine and Pathology, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.ORCID 0000-0002-5291-1469
Andrew J SaykinDepartment of Radiology and Imaging Services, Indiana University School of Medicine, 550 University Blvd, Indianapolis, IN 46202, USA.ORCID 0000-0002-1376-8532
Michael L CuccaroJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, 1501 NW 10 Ave, Miami, FL 33101, USA.ORCID 0000-0003-4769-0785
Brian W KunkleJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, 1501 NW 10 Ave, Miami, FL 33101, USA.
Margaret A Pericak-VanceJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, 1501 NW 10 Ave, Miami, FL 33101, USA.
Eden R MartinJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, 1501 NW 10 Ave, Miami, FL 33101, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison St, Chicago, IL 60612, USA.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison St, Chicago, IL 60612, USA.ORCID 0000-0002-0072-9817
Julie A SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison St, Chicago, IL 60612, USA.
William S BushCleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 2109 Adelbert Rd, Cleveland, OH 44106, USA.ORCID 0000-0002-9729-6519
Jonathan L HainesCleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, 2109 Adelbert Rd, Cleveland, OH 44106, USA.ORCID 0000-0002-4351-4728
Richard MayeuxDepartment of Neurology, The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University Medical Center and The New York Presbyterian Hospital, 710 W 168 St #3, New York, NY 10032, USA.ORCID 0000-0001-6519-9696
Badri N VardarajanDepartment of Neurology, The Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Columbia University Medical Center and The New York Presbyterian Hospital, 710 W 168 St #3, New York, NY 10032, USA.ORCID 0000-0002-5560-4085
Marilyn S AlbertDepartment of Neurology, The Johns Hopkins University School of Medicine, 550 N Broadway #415, Baltimore, MD 21205, USA.
Paul M ThompsonKeck School of Medicine, University of Southern California, 1975 Zonal Ave, Los Angeles, CA 90033, USA.ORCID 0000-0002-4720-8867
Angela L JeffersonVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 3319 West End Ave, Rm 819, Nashville, TN 37203, USA.
Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Alzheimer’s Disease Genetics Consortium (ADGC)
Alzheimer’s Disease Sequencing Project (ADSP)
Paul K CraneDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195-6420, USA.ORCID 0000-0003-4278-7465
Logan DumitrescuVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 3319 West End Ave, Rm 819, Nashville, TN 37203, USA.ORCID 0000-0002-9782-9944
Derek B ArcherVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 3319 West End Ave, Rm 819, Nashville, TN 37203, USA.ORCID 0000-0001-8638-0785
Timothy J HohmanVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 3319 West End Ave, Rm 819, Nashville, TN 37203, USA.ORCID 0000-0002-3377-7014
Leslie S GaynorVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 3319 West End Ave, Rm 819, Nashville, TN 37203, USA.ORCID 0000-0003-1121-4365
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MTranslational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Christine L MacDonald · 2021 to 2026
$80.4MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5MProject 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT, Arnold Bakker · 2014 to 2026
$51.5MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MNational Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MMVP Data Integration into the ADSP Phenotype Harmonization ConsortiumU24AG074855 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUCCARO, MICHAEL L, HOHMAN, TIMOTHY J · 2021 to 2025
$37.5MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9MResearch Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5MWisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6MNIA NIH HHS K01 AG073584NIA NIH HHS K24 AG046373NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066468NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072931NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072959NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072973NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072978NIA NIH HHS P30 AG072979NIA NIH HHS P30 AG086401NIA NIH HHS P30 AG086404NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG021155NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG027944NIA NIH HHS R01 AG028786NIA NIH HHS R01 AG037639NIA NIH HHS R01 AG054047NIA NIH HHS R01 AG056405NIA NIH HHS R01 AG059716NIA NIH HHS R01 AG062268NIA NIH HHS R01 AG064233NIA NIH HHS R01 AG067482NIA NIH HHS R01 AG079280NIA NIH HHS RF1 AG054074NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG052410NIA NIH HHS U01 AG068057NIA NIH HHS U01 AG079850NIA NIH HHS U19 AG033655NIA NIH HHS U19 AG066567NIA NIH HHS U24 AG056270NIA NIH HHS U24 AG072122NIA NIH HHS U24 AG074855NIMH NIH HHS R01 MH120794NINDS NIH HHS U01 NS100599NINDS NIH HHS UF1 NS100599NINDS NIH HHS UH2 NS100599NINDS NIH HHS UH3 NS100599
Abstract
introduction"SuperAgers" are oldest-old adults (ages 80+) whose memory performance more closely resembles middle-aged adults. The present study examined
methodsIn 18,080 participants from eight cohorts, harmonized clinical diagnostics and memory, executive function, and language domain scores were used to identify SuperAgers, cases, and controls across age-defined bins.
resultsNHW SuperAgers had significantly lower frequency of DISCUSSION: We demonstrated strong evidence that
Indexed as
Alzheimer’s diseaseAPOE genotypecognitive agingcognitive resilienceSuperAgers
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.