Evidence map›Paper›PMID 39830264›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Effect of Oxygen Saturation Targets on Neurologic Outcomes after Cardiac Arrest: A Secondary Analysis of the PILOT Trial.

Stephanie C DeMasi, Alexander T Clark, Amelia L Muhs, Jin H Han, Kipp Shipley, Jared J McKinney, Li Wang, Todd W Rice, Ari Moskowitz, Matthew E Prekker and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Stephanie C DeMasiDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-4149-8955
Alexander T ClarkDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Amelia L MuhsDivision of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University Medical Center, Nashville, TN.
Jin H HanDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN.
Kipp ShipleyDepartment of Anesthesia Vanderbilt University Medical Center, Nashville, TN.
Jared J McKinneyDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN.
Li WangDepartment of Biostatistics Vanderbilt University Medical Center, Nashville, TN.
Todd W RiceDivision of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University Medical Center, Nashville, TN.
Ari MoskowitzDivision of Critical Care Medicine, Montefiore Medical Center, Bronx, NY, USA.
Matthew E PrekkerDepartment of Emergency Medicine and Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, Hennepin County Medical Center, Minneapolis, MN, USA.
Nicholas J JohnsonDepartment of Emergency Medicine, Harborview Medical Center, University of Washington School of Medicine, Seattle, WA, USA.
Wesley H SelfDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN.
Jonathan D CaseyDivision of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University Medical Center, Nashville, TN.
Matthew W SemlerDivision of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University Medical Center, Nashville, TN.
Kevin P SeitzDivision of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University Medical Center, Nashville, TN.
Pragmatic Critical Care Research Group

Funding

Clinical and Translational Training Program in Pulmonary MedicineT32HL087738 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2007 to 2026
$7.0M
TIPS: Training in Perioperative ScienceT32GM108554 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire · 2014 to 2026
$3.7M
Bag-Mask Ventilation to PreVent Hypoxemia during Tracheal Intubation in the Emergency Department: A Clinical TrialK23HL153584 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASEY, JONATHAN DALE · 2020 to 2024
$900k
Oxygen Saturation Targets during Mechanical Ventilation of Critically Ill Adults: A Clinical TrialK23HL143053 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEMLER, MATTHEW WALL · 2018 to 2022
$854k
NHLBI NIH HHS K23 HL143053NHLBI NIH HHS K23 HL153584NHLBI NIH HHS T32 HL087738NIGMS NIH HHS T32 GM108554
6 · The paper itself

Abstract

Background: More than 600,000 adults in the United States experience a cardiac arrest each year. After resuscitation from cardiac arrest, most patients receive mechanical ventilation. The oxygenation target that optimizes neurologic outcomes after cardiac arrest is uncertain. Research Question: After cardiac arrest, does a lower oxygen saturation (SpO Study Design and Methods: We conducted a secondary analysis of patients who experienced a cardiac arrest before enrollment in the Pragmatic Investigation of optimal Oxygen Targets (PILOT) trial. The PILOT trial assigned critically ill adults receiving mechanical ventilation to a lower (88-92%), intermediate, (92-96%), or higher (96-100%) SpO Results: Of 2,987 patients in the PILOT trial, 339 (11.3%) experienced a cardiac arrest before enrollment: 221 were assigned to a lower-or-intermediate SpO Interpretation: Among patients receiving mechanical ventilation after a cardiac arrest, use of a lower-or-intermediate SpO

Indexed as

Artificial RespirationCritical IllnessFunctional statusHeart arrestOxygen/administration and dosageOxygen/therapeutic use

Identifiers

PMID39830264
PMCPMC11741503

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.