Evidence map›Paper›PMID 39830238›Full record

ArticlemedRxiv : the preprint server for health sciences2025

The Dynamics of Cognitive Decline towards Alzheimer's Disease Progression: Results from ADSP-PHC's Harmonized Cognitive Composites.

Kaidi Kang, Panpan Zhang, Logan Dumitrescu, Shubhabrata Mukherjee, Michael L Lee, Seo-Eun Choi, Emily H Trittschuh, Jesse Mez, Andrew J Saykin, Katherine A Gifford and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Kaidi KangDepartment of Biostatistics, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 1100, Nashville, TN 37203, USA.ORCID 0000-0003-0922-5727
Panpan ZhangDepartment of Biostatistics, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 1100, Nashville, TN 37203, USA.
Logan DumitrescuVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 3319 West End Avenue, 8th Floor, Nashville, TN 37203, USA.
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.
Michael L LeeDepartment of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.
Seo-Eun ChoiDepartment of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.
Emily H TrittschuhDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195-6560, USA.
Jesse MezDepartment of Neurology, Boston University School of Medicine, 85 East Concord Street, 1st floor Boston, MA 02118, USA.
Andrew J SaykinDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N. University Blvd, Room 0663, Indianapolis, IN 46202, USA.ORCID 0000-0002-1376-8532
Katherine A GiffordDepartment of Anatomy & Neurobiology, Boston University School of Medicine, 72 East Concord St, Boston, MA 02118, USA.
Rachel F BuckleyDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street Boston, MA 02114, USA.
Xiaoting GaoJanssen China Research & Development, 65 Gui-Qing Rd, Shanghai 200233, China.
Jianing DiJanssen China Research & Development, 65 Gui-Qing Rd, Shanghai 200233, China.
Paul K CraneDepartment of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA.
Timothy J HohmanVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, 3319 West End Avenue, 8th Floor, Nashville, TN 37203, USA.
Dandan LiuDepartment of Biostatistics, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 1100, Nashville, TN 37203, USA.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHRISTOPHER DIRK KEENE · 2021 to 2026
$80.4M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI Mei Cheng Wang · 2014 to 2026
$51.5M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
MVP Data Integration into the ADSP Phenotype Harmonization ConsortiumU24AG074855 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUCCARO, MICHAEL L, HOHMAN, TIMOTHY J · 2021 to 2025
$37.5M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
Rush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7M
NIA NIH HHS P01 AG003991NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG016206NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG029672NIA NIH HHS R01 AG061028NIA NIH HHS R01 AG062826NIA NIH HHS R01 AG067501NIA NIH HHS R01 AG073439NIA NIH HHS R01 AG079142NIA NIH HHS R01 AG082730NIA NIH HHS RF1 AG022018NIA NIH HHS RF1 AG027161NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG033655NIA NIH HHS U19 AG066567NIA NIH HHS U24 AG026395NIA NIH HHS U24 AG072122NIA NIH HHS U24 AG074855
6 · The paper itself

Abstract

introductionAccurately assessing temporal order of cognitive decline across multiple domains is critical in Alzheimer's disease (AD). Existing literature presented controversial conclusions likely due to the use of a single cohort and different analytical strategies.

methodsHarmonized composite cognitive measures in memory, language and executive functions from 13 cohorts in the ADSP-PHC data are used. A novel double anchoring events-based sigmoidal mixed model was developed using time to the incident of AD diagnosis as the time scale.

resultsDecline in memory occurred before decline in language which was followed by the decline in executive function. Throughout the entire AD continuum, APOE- DISCUSSION: Using harmonized data across multiple cohorts is the key to accurately characterizing the temporal order of AD biomarkers. Time to incident AD diagnosis should be used as the time scale for reproducibility purposes.

Indexed as

ADSP-PHCcognitive declineharmonized composite measuressigmoidal mixed modeltemporal order

Identifiers

PMID39830238
PMCPMC11741457

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.