Evidence map›Paper›PMID 39830112›Full record

ReviewThe Malaysian journal of medical sciences : MJMS2024

Live Attenuated Bacterial Vectors as Vehicles for DNA Vaccine Delivery: A Mini Review.

Sze Wei Eng, Vilassini Muniandy, Lohshinni Punniamoorthy, Hui Xian Tew, Mohd Nor Norazmi, Manickam Ravichandran, Su Yin Lee

Abstract readReview
In one paragraph

Review in The Malaysian journal of medical sciences : MJMS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sze Wei EngFaculty of Applied Sciences, AIMST University, Kedah, Malaysia.
Vilassini MuniandyFaculty of Applied Sciences, AIMST University, Kedah, Malaysia.
Lohshinni PunniamoorthyFaculty of Applied Sciences, AIMST University, Kedah, Malaysia.
Hui Xian TewFaculty of Applied Sciences, AIMST University, Kedah, Malaysia.
Mohd Nor NorazmiSchool of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Manickam RavichandranFaculty of Applied Sciences, AIMST University, Kedah, Malaysia.
Su Yin LeeFaculty of Applied Sciences, AIMST University, Kedah, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA vaccines are third-generation vaccines composed of plasmids that encode vaccine antigens. Their advantages include fast development, safety, stability, and cost effectiveness, which make them an attractive vaccine platform for genetic and infectious diseases. However, the low transfection efficiency of DNA vaccines results in poor performance in both larger animals and humans, thereby limiting their clinical use. To overcome this issue, live attenuated bacterial vector (LABV) has been proposed as a DNA delivery vehicle. LABV is known to improve DNA vaccine transfection efficiency, thus enhancing the immune response. This article highlights recent advancements in the development of LABV DNA vaccines, the design of shuttle plasmids and adjuvants, and the potential applications of LABV candidates.

Indexed as

delivery vehiclesDNAlive attenuated bacteriavaccine

Identifiers

PMID39830112
PMCPMC11740808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.