ArticleEuropean cells & materials
DESIGNER FAT CELLS: ADIPOGENIC DIFFERENTIATION OF CRISPR-CAS9 GENOME-ENGINEERED INDUCED PLURIPOTENT STEM CELLS.
E V Ely, A T Kapinski, S G Paradi, R Tang, F Guilak, K H Collins
Abstract read
In one paragraphArticle in European cells & materials. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors.
E V ElyDepartment of Orthopedic Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
A T KapinskiDepartment of Orthopedic Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
S G ParadiDepartment of Orthopedic Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
R TangDepartment of Orthopedic Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
F GuilakDepartment of Orthopedic Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
K H CollinsDepartment of Orthopedic Surgery, Washington University in Saint Louis, Saint Louis, MO 63110, USA.
Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MVISCOELASTIC PROPERTIES OF NORMAL AND OA CHONDRONSR01AG015768 · NIA · WASHINGTON UNIVERSITY · PI GUILAK, FARSHID · 1998 to 2022
$7.7MWashington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Alfred Hyoungju Kim · 2018 to 2026
$7.6MResource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8MThe Role of the Osteoblast Secretome in Bone FormationP30AR057235 · NIAMS · WASHINGTON UNIVERSITY · PI JOHNSON, AARON N · 2009 to 2018
$5.7MGenetically-engineered stem cells for self-regulating arthritis therapyR01AR080902 · NIAMS · WASHINGTON UNIVERSITY · PI Farshid Guilak, Christine T. Pham · 2022 to 2026
$3.7MOBESITY, BIOMECHANICS, AND INFLAMMATION IN OSTEOARTHRITISR01AG046927 · NIA · WASHINGTON UNIVERSITY · PI GUILAK, FARSHID · 2013 to 2023
$3.2MDeconstructing Cartilage Mechanotransduction by Piezo ChannelsR01AR072999 · NIAMS · WASHINGTON UNIVERSITY · PI GUILAK, FARSHID · 2020 to 2024
$2.9MImaging, Modeling and Engineering of Diabetic TissuesT32DK108742 · NIDDK · WASHINGTON UNIVERSITY · PI NICHOLS, COLIN G · 2016 to 2020
$1.4MThe Role of Fat in OsteoarthritisR00AR078949 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLINS, KELSEY HELEN-MARIE · 2023 to 2025
$715kThe Multiscale Role of Piezo Channels in Obesity-Associated Cartilage DamageF31AR079260 · NIAMS · WASHINGTON UNIVERSITY · PI ELY, ERICA VALENTINE · 2022 to 2025
$192kThe Role of Fat in OsteoarthritisK99AR078949 · NIAMS · WASHINGTON UNIVERSITY · PI COLLINS, KELSEY HELEN-MARIE · 2022 to 2023
$98kNIAMS NIH HHS F31 AR079260NIAMS NIH HHS K99 AR078949NIAMS NIH HHS P30 AR057235NIAMS NIH HHS P30 AR073752NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R00 AR078949NIAMS NIH HHS R01 AR072999NIAMS NIH HHS R01 AR080902NIA NIH HHS R01 AG015768NIA NIH HHS R01 AG046927NIDDK NIH HHS P30 DK056341NIDDK NIH HHS T32 DK108742
6 · The paper itselfAbstract
Adipose tissue is an active endocrine organ that can signal bidirectionally to many tissues and organ systems in the body. With obesity, adipose tissue can serve as a source of low-level inflammation that contributes to various co-morbidities and damage to downstream effector tissues. The ability to synthesize genetically engineered adipose tissue could have critical applications in studying adipokine signaling and the use of adipose tissue for novel therapeutic strategies. This study aimed to develop a method for non-viral adipogenic differentiation of genome-edited murine induced pluripotent stem cells (iPSCs) and to test the ability of such cells to engraft in mice
Indexed as
adipocyte differentiationadipokine secretionadipose tissuecell-based therapiesfunctional adipocytesObesitytissue engineering
Identifiers
PMID39830040
PMCPMC11741189
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