ArticleChemical engineering journal (Lausanne, Switzerland : 1996)2025
Self-Assembly Nanomedicine Initiating Cancer-Immunity Cycle with Cascade Reactions for Boosted Immunotherapy.
Article in Chemical engineering journal (Lausanne, Switzerland : 1996), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
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- Single-cell and spatial transcriptomics reveal lactate-active epithelial-immune cell crosstalk that reprograms the immune microenvironment in colorectal cancer.Translational oncology · 2026Article
- Temperature-responsive polymers for bioanalytical systems.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- Biophotocatalytic and bioelectrocatalytic strategies for methane production and oxidation: emerging pathways and perspectives.Archives of microbiology · 2026Review
- Biophotocatalytic and bioelectrocatalytic strategies for methane production and oxidation: emerging pathways and perspectives.Archives of microbiology · 2026Review
- Self-assembled nanoplatforms for cancer immunotherapy: Principles, progress and perspectives.Acta pharmaceutica Sinica. B · 2026Review
- Analytical sensing based on electrochemiluminescence.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- A ratiometric fluorescent dual-mode amplification nanosensor based on pH and oxygen testing for ultrasensitive glucose detection.Mikrochimica acta · 2026Article
- Nanozyme-based therapies for inflammatory immune disorders: opportunities and challenges.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- From Barrier to Gateway: Nanomaterials Reshaping the Tumor Microenvironment for Therapy.International journal of nanomedicine · 2026Review
- Targeting cuproptosis opens a new chapter of nanomedicine: a scientometric and graphical analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Wearable sensors: in situ detection tools for plant physiological markers and growth environment information.Mikrochimica acta · 2025Review
- Molecular engineering of multifunctional benzothiazole-sulfonamide hybrids: from synthesis to optoelectronic applications.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Influence of metal ions on the economic parameters of mulberry silkworm Bombyx mori (Lepidoptera: Bombycidae).Biologia futura · 2025Article
- Facile and label-free electrochemical detection of myasthenia gravis-associated AChR antibodies using a laser-induced graphene immunoplatform.Mikrochimica acta · 2025Article
- Medium-Entropy Engineering Enhances Na⁺/Electron Transport in NaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A portable electrochemical device with UiO-66@polydopamine modified screen-printed electrodes for rapid detection of manganese ions.Mikrochimica acta · 2025Article
- PTEN as a prognostic factor for radiotherapy plus immunotherapy response in nasopharyngeal carcinoma.Journal of nanobiotechnology · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Immune checkpoint blockade (ICB) therapy has been extensively integrated into cancer clinical management. However, its overall response rate is limited due to the stagnating cancer-immunity cycle (CIC) caused by the immunosuppressive tumor microenvironment (TME). Here, a multi-pronged nanomedicine, defined as LCCS, was constructed by the self-assembly of lactate oxidase, catalase, chlorin e6, and sorafenib. Through cascade reactions, LCCS effectively reprogrammed the TME and re-initiated the CIC by depleting lactate, alleviating hypoxia, inducing immunogenic cell death, and normalizing tumor vessels. Immunological analyses indicated that treatment with LCCS decreased the infiltration of immunosuppressive cells while increasing the recruitment of immune effector cells in tumors. Leveraging the effective operation of the CIC, LCCS improved the efficacy of ICB therapy to inhibit breast cancer, and effectively induced the elimination of colorectal cancer and long-term immune memory. Therefore, multifunctional nanomedicines targeting CIC hold great potential for applications in cancer immunotherapy.
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Registered trials
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