Evidence map›Paper›PMID 39829922›Full record

ArticlebioRxiv : the preprint server for biology2025

Dose-dependent sensitivity of human 3D chromatin to a heart disease-linked transcription factor.

Zoe L Grant, Shuzhen Kuang, Shu Zhang, Abraham J Horrillo, Kavitha S Rao, Vasumathi Kameswaran, Carine Joubran, Pik Ki Lau, Keyi Dong, Bing Yang and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Zoe L GrantGladstone Institutes; San Francisco, CA, USA.ORCID 0000-0003-0580-5222
Shuzhen KuangGladstone Institutes; San Francisco, CA, USA.
Shu ZhangGladstone Institutes; San Francisco, CA, USA.
Abraham J HorrilloGladstone Institutes; San Francisco, CA, USA.
Kavitha S RaoGladstone Institutes; San Francisco, CA, USA.ORCID 0000-0001-5401-6989
Vasumathi KameswaranGladstone Institutes; San Francisco, CA, USA.
Carine JoubranGladstone Institutes; San Francisco, CA, USA.
Pik Ki LauDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine; La Jolla, CA, USA.
Keyi DongDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine; La Jolla, CA, USA.
Bing YangDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine; La Jolla, CA, USA.
Weronika M BartosikDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine; La Jolla, CA, USA.
Nathan R ZemkeDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine; La Jolla, CA, USA.
Bing RenDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine; La Jolla, CA, USA.
Irfan S KathiriyaGladstone Institutes; San Francisco, CA, USA.ORCID 0000-0003-1207-1490
Katherine S PollardGladstone Institutes; San Francisco, CA, USA.
Benoit G BruneauGladstone Institutes; San Francisco, CA, USA.ORCID 0000-0002-0804-7597

Funding

Center for Integrated Multi-modal and Multi-scale Nucleome ResearchUM1HG011585 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DULAC, CATHERINE, LEIN, ED · 2020 to 2024
$6.7M
Genetic determinants of 4D genome folding in human cardiac developmentU01HL157989 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN, POLLARD, KATHERINE S. · 2020 to 2024
$3.8M
Gene regulatory networks for heart developmentR01HL155906 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI BRUNEAU, BENOIT GAETAN · 2021 to 2024
$2.4M
Illumina NovaSeq 6000 Sequencing SystemS10OD028511 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOW, ERIC D · 2020 to 2020
$583k
BD FACSAria II Flow CytometerS10RR028962 · NCRR · J. DAVID GLADSTONE INSTITUTES · PI CAVROIS, MARIELLE · 2011 to 2011
$544k
NCRR NIH HHS S10 RR028962NHGRI NIH HHS UM1 HG011585NHLBI NIH HHS R01 HL155906NHLBI NIH HHS U01 HL157989NIH HHS S10 OD028511
6 · The paper itself

Abstract

Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human developmental disorders, and cell-type specific gene regulation is linked to the reorganization of 3D chromatin during cellular differentiation. Here, we show dose-dependent regulation of chromatin organization by the congenital heart disease (CHD)-linked, lineage-restricted TF TBX5 in human cardiomyocyte differentiation. Genome organization, including compartments, topologically associated domains, and chromatin loops, are sensitive to reduced

Identifiers

PMID39829922
PMCPMC11741296

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.