Evidence map›Paper›PMID 39829893›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular and structural basis of a subfamily of PrfH rescuing both the damaged and intact ribosomes stalled in translation.

Yannan Tian, Qingrong Li, Shirin Fatma, Junyi Jiang, Hong Jin, Fuxing Zeng, Raven H Huang

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PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yannan TianDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Qingrong LiDepartment of Systems Biology, Southern University of Science and Technology, Shenzhen, 518055, P.R. China.
Shirin FatmaDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Junyi JiangDepartment of Systems Biology, Southern University of Science and Technology, Shenzhen, 518055, P.R. China.
Hong JinDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Fuxing ZengDepartment of Systems Biology, Southern University of Science and Technology, Shenzhen, 518055, P.R. China.
Raven H HuangDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Funding

Mechanisms of Translational Activation by Decapping ActivatorsR01GM120552 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI JIN, HONG · 2016 to 2020
$1.5M
Rescue and repair of stalled ribosome damaged by ribosome-specific ribotoxinsR01GM145060 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI HUANG, RAVEN H · 2022 to 2025
$1.3M
Genome-wide profiling of RNA damage and repair in vivoU01GM120764 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI HUANG, RAVEN H · 2016 to 2019
$1.1M
NIGMS NIH HHS R01 GM120552NIGMS NIH HHS R01 GM145060NIGMS NIH HHS U01 GM120764
6 · The paper itself

Abstract

In bacteria, spontaneous mRNAs degradation and ribotoxin-induced RNA damage are two main biological events that lead to the stall of protein translation. The ubiquitous trans-translation system as well as several alternative rescue factors (Arfs) are responsible for rescuing the stalled ribosomes caused by truncated mRNAs that lack the stop codons. To date, protein release factor homolog (PrfH) is the only factor known to rescue the stalled ribosome damaged by ribotoxins. Here we show that a subfamily of PrfH, exemplified by PrfH from

Identifiers

PMID39829893
PMCPMC11741408

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.