Evidence map›Paper›PMID 39829874›Full record

ArticlebioRxiv : the preprint server for biology2025

Enhanced yield and subtype identity of hPSC-derived midbrain dopamine neuron by modulation of WNT and FGF18 signaling.

Tae Wan Kim, Jinghua Piao, Vittoria D Bocchi, So Yeon Koo, Se Joon Choi, Fayzan Chaudhry, Donghe Yang, Hyein S Cho, Emiliano Hergenreder, Lucia Ruiz Perera and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Jinghua Piao
Vittoria D Bocchi
So Yeon Koo
Se Joon Choi
Fayzan Chaudhry
Donghe Yang
Hyein S Cho
Emiliano Hergenreder
Lucia Ruiz Perera
Subhashini Joshi
Zaki Abou Mrad
Nidia Claros
Shkurte Ademi Donohue
Anika K Frank
Ryan Walsh
Eugene V Mosharov
Doron Betel
Viviane Tabar

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Directing Fate, Subtype Identity and Survival in Human Pluripotent-Derived Midbrain Dopamine NeuronsR01NS118067 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI BETEL, DORON, STUDER, LORENZ P. · 2021 to 2025
$3.2M
Human Dopamine Grafts in Alpha-Synuclein Models of Parkinson DiseaseR01NS126588 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI VIVIANE TABAR · 2023 to 2026
$2.6M
NCI NIH HHS P30 CA008748NINDS NIH HHS R01 NS118067NINDS NIH HHS R01 NS126588
6 · The paper itself

Abstract

While clinical trials are ongoing using human pluripotent stem cell-derived midbrain dopamine (mDA) neuron precursor grafts in Parkinson's disease (PD), current protocols to derive mDA neurons remain suboptimal. In particular, the yield of TH+ mDA neurons after

Identifiers

PMID39829874
PMCPMC11741396

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.