Evidence map›Paper›PMID 39829838›Full record

ArticlebioRxiv : the preprint server for biology2025

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis.

Mike Lange, Michele Wölk, Cody E Doubravsky, Joseph M Hendricks, Shunji Kato, Yurika Otoki, Benjamin Styler, Kiyotaka Nakagawa, Maria Fedorova, James A Olzmann

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Mike LangeDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Michele WölkCenter of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden Dresden, Germany.
Cody E DoubravskyDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Joseph M HendricksDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Shunji KatoLaboratory of Food Function Analysis, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Yurika OtokiLaboratory of Food Function Analysis, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Benjamin StylerDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Kiyotaka NakagawaLaboratory of Food Function Analysis, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Maria FedorovaCenter of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden Dresden, Germany.
James A OlzmannDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-7751-8316

Funding

Molecular Mechanisms of Lipid Droplet BiogenesisR01GM112948 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI OLZMANN, JAMES A · 2015 to 2024
$3.1M
NIGMS NIH HHS R01 GM112948
6 · The paper itself

Abstract

Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of LD neutral lipids to peroxidation and protective mechanisms are unknown. Here, we identify LD-localized Ferroptosis Suppressor Protein 1 (FSP1) as a critical regulator that prevents neutral lipid peroxidation by recycling coenzyme Q10 (CoQ10) to its lipophilic antioxidant form. Lipidomics reveal that FSP1 loss leads to the accumulation of oxidized triacylglycerols and cholesteryl esters, and biochemical reconstitution of FSP1 with CoQ10 and NADH suppresses triacylglycerol peroxidation

Identifiers

PMID39829838
PMCPMC11741373

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.