Evidence map›Paper›PMID 39829837›Full record

ArticlebioRxiv : the preprint server for biology2025

Non-mutated human tau stimulates Alzheimer's disease-relevant neurodegeneration in a microglia-dependent manner.

Ethan R Roy, Qiang Wang, Kexin Huang, Sanming Li, Yuanyuan Fan, Estrella Escobar, Shuning Huang, Juan J Herrera, Wenbo Li, Clare Pridans and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Ethan R RoyDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Qiang WangDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Kexin HuangMcWilliams School of Biomedical Informatics at UTHealth Houston, Houston, TX, USA.
Sanming LiDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Yuanyuan FanDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Estrella EscobarDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Shuning HuangDepartment of Diagnostic & Interventional Imaging, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Juan J HerreraDepartment of Diagnostic & Interventional Imaging, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Wenbo LiDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Clare PridansUniversity of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, UK.
Xiaobo ZhouMcWilliams School of Biomedical Informatics at UTHealth Houston, Houston, TX, USA.
Cynthia JuDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Wei CaoDepartment of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-8952-9159

Funding

Antiviral response coupled with transposon derepression in Alzheimer’s disease and agingR01AG074283 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CAO, WEI · 2021 to 2025
$3.2M
Interrogating the Interferon Pathway in Aging and Alzheimer's DiseaseRF1AG057587 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CAO, WEI, ZHENG, HUI · 2018 to 2018
$2.9M
microRNA miR-147 Dampens Alveolar Epithelial Inflammation During ARDSR01HL154720 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2021 to 2024
$2.2M
Role of chitinase-3-like-1 (Chi3l1) in acetaminophen-induced liver injuryR01DK122708 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JU, CYNTHIA · 2019 to 2023
$2.0M
NHLBI NIH HHS R01 HL154720NIA NIH HHS R01 AG074283NIA NIH HHS RF1 AG057587NIDDK NIH HHS R01 DK122708
6 · The paper itself

Abstract

The accumulation of abnormal, non-mutated tau protein is a key pathological hallmark of Alzheimer's disease (AD). Despite its strong association with disease progression, the mechanisms by which tau drives neurodegeneration in the brain remain poorly understood. Here, we selectively expressed non-mutated or mutated human microtubule-associated protein tau (

Indexed as

AlzheimerFIRE micemicroglianeurodegenerationneuroinflammationTautauopathy

Identifiers

PMID39829837
PMCPMC11741277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.