Evidence map›Paper›PMID 39829826›Full record

ArticlebioRxiv : the preprint server for biology2025

Foxi2 and Sox3 are master regulators controlling ectoderm germ layer specification.

Clark L Hendrickson, Ira L Blitz, Amina Hussein, Kitt D Paraiso, Jin Cho, Michael W Klymkowsky, Matthew J Kofron, Ken W Y Cho

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Clark L HendricksonDevelopmental and Cell Biology, University of California, Irvine, CA, USA.
Ira L BlitzDevelopmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0002-0173-3287
Amina HusseinDevelopmental and Cell Biology, University of California, Irvine, CA, USA.
Kitt D ParaisoDevelopmental and Cell Biology, University of California, Irvine, CA, USA.
Jin ChoDevelopmental and Cell Biology, University of California, Irvine, CA, USA.
Michael W KlymkowskyMolecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO, USA.
Matthew J KofronDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH USA.
Ken W Y ChoDevelopmental and Cell Biology, University of California, Irvine, CA, USA.ORCID 0000-0001-7282-1770

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
Mentor Training to enhance mentorship in an interdisciplinary training programT32GM136624 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Arthur D Lander, Qing Nie · 2020 to 2026
$3.1M
Zygotic Genome Activation by Maternal Transcription Factors and Epigenetic ModifiersR35GM139617 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Ken W.Y. Cho · 2021 to 2026
$2.6M
Mechanisms of Foxh1 pioneer factor action during mesendoderm developmentR01GM126395 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHO, KEN W.Y. · 2017 to 2020
$1.6M
PacBio RS Single Molecule, Real-Time (SMRT) DNA SequencerS10OD010794 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2012 to 2012
$600k
High-Throughput DNA SequencerS10OD021718 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2016 to 2016
$600k
Spatiotemporal mapping of enhancer activity in developing frog embryosR21HD109696 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHO, KEN W.Y. · 2022 to 2023
$417k
NCI NIH HHS P30 CA062203NIAMS NIH HHS P30 AR075047NICHD NIH HHS R21 HD109696NIGMS NIH HHS R01 GM126395NIGMS NIH HHS R35 GM139617NIGMS NIH HHS T32 GM136624NIH HHS S10 OD010794NIH HHS S10 OD021718
6 · The paper itself

Abstract

In vertebrates, germ layer specification represents a critical transition where pluripotent cells acquire lineage-specific identities. We identify the maternal transcription factors Foxi2 and Sox3 to be pivotal master regulators of ectodermal germ layer specification in

Indexed as

cis-regulatory modulesEp300epigeneticsgerm layersinner ectodermmaternal transcription factorsneuroectodermnon-neural ectodermouter ectodermSingle nucleus RNA-seqsuper enhancersXenopus

Identifiers

PMID39829826
PMCPMC11741269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.