Evidence map›Paper›PMID 39829805›Full record

ArticlebioRxiv : the preprint server for biology2025

Bacterial and host enzymes modulate the inflammatory response produced by the peptidoglycan of the Lyme disease agent.

Joshua W McCausland, Zachary A Kloos, Irnov Irnov, Nicole D Sonnert, Junhui Zhou, Rachel Putnick, Elizabeth A Mueller, Allen C Steere, Noah W Palm, Catherine L Grimes and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Joshua W McCauslandSarafan ChEM-H Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6585-0506
Zachary A KloosMicrobiology Program, Yale University, West Haven, Connecticut, USA.ORCID 0000-0002-8273-5830
Irnov IrnovSarafan ChEM-H Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8631-4075
Nicole D SonnertMicrobiology Program, Yale University, West Haven, Connecticut, USA.ORCID 0000-0002-2781-4675
Junhui ZhouDepartment of Chemistry and Biochemistry, University of Delaware, Neward, DE.
Rachel PutnickDepartment of Chemistry and Biochemistry, University of Delaware, Neward, DE.
Elizabeth A MuellerSarafan ChEM-H Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5482-6551
Allen C SteereDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-5268-9853
Noah W PalmDepartment of Immunology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7262-9455
Catherine L GrimesDepartment of Chemistry and Biochemistry, University of Delaware, Neward, DE.ORCID 0000-0002-0586-2879
Christine Jacobs-WagnerSarafan ChEM-H Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0980-5334

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Peptidoglycan Fragment Library to Investigate Innate Immune ResponsesR01GM138599 · NIGMS · UNIVERSITY OF DELAWARE · PI GRIMES, CATHERINE LEIMKUHLER, REINECKER, HANS-CHRISTIAN · 2020 to 2023
$2.0M
NIGMS NIH HHS R01 GM138599NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

The spirochete

Identifiers

PMID39829805
PMCPMC11741416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.