Evidence map›Paper›PMID 39829802›Full record

ArticlebioRxiv : the preprint server for biology2025

Landscape and regulation of mRNA translation in the early

Yash Shukla, Vighnesh Ghatpande, Cindy F Hu, Daniel J Dickinson, Can Cenik

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yash ShuklaDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Vighnesh GhatpandeDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Cindy F HuDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.
Daniel J DickinsonDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0003-2651-2584
Can CenikDepartment of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-6370-0889

Funding

Understanding developmental control of cell polarity using single-cell in vivo biochemistryR01GM138443 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI DICKINSON, DANIEL J · 2020 to 2025
$2.4M
Single cell quantification of translation control in early mouse developmentR35GM150667 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Can Cenik · 2023 to 2026
$1.6M
Translational regulation of limb bud initiationR21HD110096 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI CENIK, CAN, VOKES, STEVEN ALEXANDER · 2022 to 2023
$436k
NICHD NIH HHS R21 HD110096NIGMS NIH HHS R01 GM138443NIGMS NIH HHS R35 GM150667
6 · The paper itself

Abstract

Animal embryos rely on regulated translation of maternally deposited mRNAs to drive early development. Using low-input ribosome profiling combined with RNA sequencing on precisely staged embryos, we measured mRNA translation during the first four cell cycles of

Indexed as

C. eleganscell fate determinationembryogenesismaternal transcriptsmRNA translationOMA-1P-granulespost-transcriptional controlRibo-ITPribosome profilingtranslational regulation

Identifiers

PMID39829802
PMCPMC11741243

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.