Evidence map›Paper›PMID 39829799›Full record

ArticlebioRxiv : the preprint server for biology2025

Generation and Characterization of a Knockout Mouse of an Enhancer of

Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Emily Cordova HurtadoDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Janine M WottonThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Alexander GulkaDepartment of Biology, Emory University. Atlanta, GA 30322, USA.
Crystal BurkeThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Jeffrey K NgDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ibrahim BahDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Juana ManuelDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hillary HeinsDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Stephen A MurrayThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
David U GorkinDepartment of Biology, Emory University. Atlanta, GA 30322, USA.
Jacqueline K WhiteThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Kevin A PetersonThe Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Tychele N TurnerDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-8246-6477

Funding

The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2)UM1OD023222 · OD · JACKSON LABORATORY · PI ROBERT E BRAUN, Stephen A Murray · 2016 to 2026
$47.2M
Noncoding mutations in neurodevelopmental disordersR01MH126933 · NIMH · WASHINGTON UNIVERSITY · PI Tychele Naomi Turner · 2022 to 2026
$3.6M
Single-cell epigenomic phenotyping of IMPC-generated mouse lines lacking chromatin regulatorsR01HD102534 · NICHD · EMORY UNIVERSITY · PI GORKIN, DAVID USCHER · 2021 to 2025
$3.4M
Nature and contribution of noncoding, regulatory mutations in neurodevelopmental disordersR00MH117165 · NIMH · WASHINGTON UNIVERSITY · PI TURNER, TYCHELE NAOMI · 2019 to 2021
$743k
NICHD NIH HHS R01 HD102534NIH HHS UM1 OD023222NIMH NIH HHS R00 MH117165NIMH NIH HHS R01 MH126933
6 · The paper itself

Abstract

Genomic studies of autism and other neurodevelopmental disorders have identified several relevant protein-coding and noncoding variants. One gene with an excess of protein-coding

Identifiers

PMID39829799
PMCPMC11741297

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.