Evidence map›Paper›PMID 39829796›Full record

ArticlebioRxiv : the preprint server for biology2025

High-throughput protein binder discovery by rapid in vivo selection.

Matthew J Styles, Joshua A Pixley, Tongyao Wei, Christopher Basile, Shannon S Lu, Bryan C Dickinson

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Matthew J StylesDepartment of Chemistry, University of Chicago, 5735 S. Ellis Ave., Chicago, IL 60637.ORCID 0000-0003-3236-0425
Joshua A PixleyDepartment of Chemistry, University of Chicago, 5735 S. Ellis Ave., Chicago, IL 60637.ORCID 0009-0000-4564-5345
Tongyao WeiDepartment of Chemistry, University of Chicago, 5735 S. Ellis Ave., Chicago, IL 60637.ORCID 0000-0002-0602-6979
Christopher BasileDepartment of Chemistry, University of Chicago, 5735 S. Ellis Ave., Chicago, IL 60637.ORCID 0009-0009-9764-4745
Shannon S LuDepartment of Chemistry, University of Chicago, 5735 S. Ellis Ave., Chicago, IL 60637.ORCID 0000-0003-1556-7520
Bryan C DickinsonDepartment of Chemistry, University of Chicago, 5735 S. Ellis Ave., Chicago, IL 60637.ORCID 0000-0002-9616-1911

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI KUNLE ODUNSI · 1985 to 2026
$122.1M
Rapid selection approaches to understand and reprogram proteins and peptidesR35GM119840 · NIGMS · UNIVERSITY OF CHICAGO · PI Bryan Dickinson · 2016 to 2026
$4.8M
Development of evolutionary technologies to reprogram protein-protein interactionsF32GM147968 · NIGMS · UNIVERSITY OF CHICAGO · PI STYLES, MATTHEW J · 2022 to 2025
$219k
NCI NIH HHS P30 CA014599NIGMS NIH HHS F32 GM147968NIGMS NIH HHS R35 GM119840
6 · The paper itself

Abstract

Proteins that selectively bind to a target of interest are foundational components of research pipelines

Identifiers

PMID39829796
PMCPMC11741316

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.