Evidence map›Paper›PMID 39829761›Full record

ArticlebioRxiv : the preprint server for biology2025

SLFN11-mediated tRNA regulation induces cell death by disrupting proteostasis in response to DNA-damaging agents.

Yuki Iimori, Teppei Morita, Takeshi Masuda, Shojiro Kitajima, Nobuaki Kono, Shun Kageyama, Josephine Galipon, Atsuo T Sasaki, Akio Kanai

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yuki IimoriInstitute for Advanced Biosciences, Keio University, Tsuruoka, 997-0017, Japan.
Teppei MoritaInstitute for Advanced Biosciences, Keio University, Tsuruoka, 997-0017, Japan.
Takeshi MasudaInstitute for Advanced Biosciences, Keio University, Tsuruoka, 997-0017, Japan.
Shojiro KitajimaInstitute for Advanced Biosciences, Keio University, Tsuruoka, 997-0017, Japan.
Nobuaki KonoInstitute for Advanced Biosciences, Keio University, Tsuruoka, 997-0017, Japan.ORCID 0000-0001-5960-7956
Shun KageyamaInstitute for Advanced Biosciences, Keio University, Tsuruoka, 997-0017, Japan.
Josephine GaliponInstitute for Advanced Biosciences, Keio University, Tsuruoka, 997-0017, Japan.ORCID 0000-0002-6280-7446
Atsuo T SasakiInstitute for Advanced Biosciences, Keio University, Tsuruoka, 997-0017, Japan.
Akio KanaiInstitute for Advanced Biosciences, Keio University, Tsuruoka, 997-0017, Japan.ORCID 0000-0002-6362-2419

Funding

Mechanistic role of phosphatidylinositol 5-phosphate 4-kinase beta in GTP-dependent lysosomal acidification for stress-resilient cell growth and metabolismR01GM144426 · NIGMS · UNIVERSITY OF CINCINNATI · PI Atsuo Sasaki · 2023 to 2026
$1.7M
NIGMS NIH HHS R01 GM144426
6 · The paper itself

Abstract

DNA-damaging agents (DDAs) have long been used in cancer therapy. However, the precise mechanisms by which DDAs induce cell death are not fully understood and drug resistance remains a major clinical challenge. Schlafen 11 (SLFN11) was identified as the gene most strongly correlated with the sensitivity to DDAs based on mRNA expression levels. SLFN11 sensitizes cancer cells to DDAs by cleaving and downregulating tRNA

Identifiers

PMID39829761
PMCPMC11741311

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.