Evidence map›Paper›PMID 39829749›Full record

ArticlebioRxiv : the preprint server for biology2025

Human REXO4 is Required for Cell Cycle Progression.

Kevin M Clutario, Mai Abdusamad, Ivan Ramirez, Kayla J Rich, Ankur A Gholkar, Julian Zaragoza, Jorge Z Torres

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kevin M ClutarioDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
Mai AbdusamadDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
Ivan RamirezDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
Kayla J RichDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
Ankur A GholkarDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
Julian ZaragozaDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
Jorge Z TorresDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-2158-889X

Funding

TUMOR CELL SURFACES AND CHROMOSOMEST32CA009056 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gay M Crooks, David A. Nathanson · 1985 to 2026
$10.5M
Research Training in Cell and Molecular BiologyT32GM145388 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jorge Torres · 2022 to 2026
$5.2M
Investigating the Cell Division MachineryR35GM139539 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 2021 to 2025
$2.2M
Defining the role of DUSP12 in the regulation of cell division and apoptosis.F31GM154466 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABDUSAMAD, MAI · 2024 to 2025
$66k
NCI NIH HHS T32 CA009056NIGMS NIH HHS F31 GM154466NIGMS NIH HHS R35 GM139539NIGMS NIH HHS T32 GM145388
6 · The paper itself

Abstract

Human REXO4 is a poorly characterized exonuclease that is overexpressed in human cancers. To better understand the function of REXO4 and its relationship to cellular proliferation, we have undertaken multidisciplinary approaches to characterize its cell cycle phase-dependent subcellular localization and the cis determinants required for this localization, its importance to cell cycle progression and cell viability, its protein-protein association network, and its activity. We show that the localization of REXO4 to the nucleolus in interphase depends on an N-terminal nucleolar localization sequence and that its localization to the perichromosomal layer of mitotic chromosomes is dependent on Ki67. Depletion of REXO4 led to a G1/S cell cycle arrest, and reduced cell viability. REXO4 associated with ribosome components and other proteins involved in rRNA metabolism. We propose a model where REXO4 is important for proper rRNA processing, which is required for ribosome biogenesis, cell cycle progression, and proliferation.

Indexed as

cell cyclecell divisionREXO4ribosome biogenesisRNA exonucleaserRNA

Identifiers

PMID39829749
PMCPMC11741406

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.