Evidence map›Paper›PMID 39829684›Full record

ArticleAnimal behaviour2025

Associations between social behaviour and proinflammatory immune activation are modulated by age in a free-ranging primate population.

Eve B Cooper, Connor Whalen, Nina Beeby, Josué E Negron-Del Valle, Daniel Phillips, Cayo Biobank Research Unit, Noah Snyder-Mackler, Lauren J N Brent, James P Higham

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal behaviour, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Early life adversity shapes adult behavior in a free-ranging primate.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eve B CooperDepartment of Anthropology, New York University, New York, NY, U.S.A.
Connor WhalenDepartment of Anthropology, New York University, New York, NY, U.S.A.
Nina BeebyThe New York Consortium in Evolutionary Primatology (NYCEP), New York, NY, U.S.A.
Josué E Negron-Del ValleCenter for Evolution and Medicine, Arizona State University, Tempe, AZ, U.S.A.
Daniel PhillipsCenter for Evolution and Medicine, Arizona State University, Tempe, AZ, U.S.A.
Cayo Biobank Research Unit
Noah Snyder-MacklerCenter for Evolution and Medicine, Arizona State University, Tempe, AZ, U.S.A.
Lauren J N BrentCentre for Research in Animal Behaviour, University of Exeter, Exeter, U.K.
James P HighamDepartment of Anthropology, New York University, New York, NY, U.S.A.

Funding

Translational Science InitiativeP40OD012217 · OD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CARLOS A SARIOL · 2012 to 2026
$40.4M
Recovering, Reestablishing and Modernizing the Caribbean Primate Research Center as an act of resiliency after Hurricane MariaC06OD026690 · OD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI MARTINEZ, MELWEEN I. · 2018 to 2018
$5.8M
Social modifiers of the pace of aging across multiple domains and tissuesR01AG060931 · NIA · UNIVERSITY OF WASHINGTON · PI BRENT, LAUREN JOHANNA NICOLE, HIGHAM, JAMES P · 2019 to 2023
$3.6M
Impacts of hurricanes and social buffering on biological aging in a free-ranging animal modelR01AG084706 · NIA · NEW YORK UNIVERSITY · PI Lauren Johanna Nicole Brent, James P Higham · 2023 to 2026
$2.5M
Neurogenomics of Vulnerability and Resilience to Mental Health Syndromes in Response to Extreme Life EventsR01MH118203 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI PLATT, MICHAEL L · 2019 to 2023
$1.9M
Effects of a major natural disaster on the pace of aging in a nonhuman primate modelR56AG071023 · NIA · NEW YORK UNIVERSITY · PI BRENT, LAUREN JOHANNA NICOLE, HIGHAM, JAMES P · 2021 to 2021
$839k
Gene regulatory analysis of social integration and resilience during agingR00AG051764 · NIA · UNIVERSITY OF WASHINGTON · PI SNYDER-MACKLER, NOAH · 2017 to 2019
$746k
NIA NIH HHS R00 AG051764NIA NIH HHS R01 AG060931NIA NIH HHS R01 AG084706NIA NIH HHS R56 AG071023NIH HHS C06 OD026690NIH HHS P40 OD012217NIMH NIH HHS R01 MH118203
6 · The paper itself

Abstract

The effect of the social environment on the proinflammatory immune response may mediate the relationship between social environment and fitness but remains understudied outside captive animals and human populations. Age can also influence both immune function and social behaviour, and hence may modulate their relationships. This study investigates the role of social interactions in driving the concentrations of two urinary markers of proinflammatory immune activation, neopterin and soluble urokinase plasminogen activator receptor (suPAR), in a free-ranging population of rhesus macaques,

Indexed as

affiliationageingagonismimmune responseneopterinrhesus macaquesocial bufferingsocialitysuPAR

Identifiers

PMID39829684
PMCPMC11741183

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.