ArticleVeterinary world2024
The oncolytic effect of Newcastle disease virus attenuated AMHA1 strain against digestive system tumors.
Article in Veterinary world, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Mesenchymal and neural stem cell differentiation into Purkinje-like cells: Morphological study.Journal of Taibah University Medical Sciences · 2026Article
- The role and mechanism of neutrophils in oncolytic virus therapy.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Isolation and Molecular Detection of Newcastle Disease Virus From Outbreak Cases in Selected Areas of Northern and Western Oromia, Ethiopia.Veterinary medicine and science · 2026Article
- Natural killer cell activated by attenuated newcastle disease virus (NDV) as anti-cancer therapy.Frontiers in molecular biosciences · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aim: Malignant diseases are among the most common and deadly illnesses that are often spread due to lifestyle choices. These diseases are caused by unchecked cell growth, which can be curable if detected early. Cancer treatment is dependent on various internal and external factors. Newcastle disease virus (NDV) has emerged as a promising virotherapeutic agent due to its oncolytic activity and safety profile. This study investigated the ability of virulent NDV to infect, replicate, and kill digestive tumor cells in esophageal and colorectal cancers. Materials and Methods: NDV was used at several concentrations (multiplicities of infection [MOI]: 1, 3, 5, 10, and 20) on two models of tumor cells: colorectal carcinoma (HRT) and esophageal carcinoma (SK-GT). The investigation focused on the cytotoxic effects of NDV in these cell lines. Results: The results indicated that SK-GT carcinoma cells (esophageal and colorectal carcinoma) exhibited a high cytotoxic response to NDV, which was directly proportional to the MOI concentration. The half-maximal inhibitory concentration of NDV was 5.736 for the SK-GT cell line and 9.878 for the HRT cell line. Conclusion: NDV can replicate and kill cancer cells in esophageal and colorectal cancers. We recommend conducting
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