Evidence map›Paper›PMID 39829638›Full record

ArticleOpen forum infectious diseases2025

Missed and Delayed Diagnoses of Acute Human Immunodeficiency Virus (HIV) Infection in a Southern Opt-Out HIV Testing Environment Without Reflex HIV RNA Testing.

Sarah F Gruber, Eli P Wilber, Brittany Smith, Paulina A Rebolledo, Jonathan A Colasanti, Rishika Iytha, Megan Schwinne, Chad Robichaux, Meredith H Lora

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah F GruberDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0009-0009-5088-5306
Eli P WilberDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-8413-2681
Brittany SmithGrady Health System, Atlanta, Georgia, USA.
Paulina A RebolledoDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Jonathan A ColasantiDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Rishika IythaDepartment of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.ORCID https://orcid.org/0009-0006-8070-5511
Megan SchwinneDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0009-0004-6719-8821
Chad RobichauxDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID https://orcid.org/0009-0002-8403-5499
Meredith H LoraDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
NCATS NIH HHS UL1 TR002378
6 · The paper itself

Abstract

Prompt confirmation of human immunodeficiency virus (HIV) is critical. We examined 10 years of discordant results without reflex HIV RNA. Of patients with acute HIV infection, 43.9% (95% confidence interval, 36.2%-52.0%) had confirmation delays >30 days or were never confirmed, indicating a need for reflex RNA to facilitate diagnosis.

Indexed as

acute HIV infectiondiscordant resultsHIV diagnostic delayHIV testingreflex HIV RNA

Identifiers

PMID39829638
PMCPMC11739807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.