ArticleInternational journal of ophthalmology2025
Autophagy serves as a protective effect against inflammatory injury of oxidative stress in ARPE-19 cell.
Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
aimTo test the effect of autophagy on inflammatory damage resulting from oxidative stress in adult retinal pigment epithelial cell line (ARPE-19).
methodsARPE-19 cells were pretreated with 200 and 600 µmol/L hydrogen peroxide (H
resultsThe levels of ROS, cytokines (TNFα, IL-6, and TGFβ), and autophagic activity were significantly increased in ARPE-19 cells after pretreated with H
conclusionAutophagy demonstrates a protective effect on ARPE-19 cell through mitigating oxidative damage and oxidative stress-induced inflammatory response. Regulation of autophagy may be a potential way for age-related macular degeneration.
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