Evidence map›Paper›PMID 39829602›Full record

ArticleACS omega2025

Preparing and Characterizing of Xyloglucan Films Containing Tea Extract for Oral Mucositis.

Kaoru Hirose, Rieko Nitto, Shohtaro Yokota, Yayoi Kawano, Kazuhiko Yamatoya, Akira Tabuchi, Yumeo Suzuki, Takehisa Hanawa

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kaoru HiroseFaculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 2788510, Japan.ORCID https://orcid.org/0000-0003-4437-1885
Rieko NittoFaculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 2788510, Japan.
Shohtaro YokotaFaculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 2788510, Japan.
Yayoi KawanoFaculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 2788510, Japan.
Kazuhiko YamatoyaMP Gokyo Food & Chemical Co., Ltd., Osaka, Kita-ku 5300001, Japan.
Akira TabuchiMP Gokyo Food & Chemical Co., Ltd., Osaka, Kita-ku 5300001, Japan.
Yumeo SuzukiMP Gokyo Food & Chemical Co., Ltd., Osaka, Kita-ku 5300001, Japan.
Takehisa HanawaFaculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 2788510, Japan.ORCID https://orcid.org/0000-0002-3922-025X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to prepare films using Xyloglucan (Xylo) and tea extract (TE) to treat aphthous stomatitis without causing discomfort. Xylo, which gelates by adding polyphenol, was used as a gelation agent, and TE, which contains epigallocatechin-3-gallate (EGCG) with antioxidant properties, was used as an active pharmaceutical agent. Two kinds of films, hydrogel and xerogel films, were prepared by mixing various amounts of Xylo and TE. Their gelling behavior and physicochemical properties were evaluated. The sol-gel transition temperature increased with increased TE content, and the rupture strength of the films increased with increasing Xylo and TE concentrations. Rapid water absorption and high adhesiveness were observed during the reconstruction process from the xerogel to the hydrogel. The concentrations of Xylo and TE controlled the formulations' physicochemical properties and the EGCG release rate. These results concluded that the xerogel prepared by using Xylo and TE could be applied as an oral mucosal adherent film formulation.

Identifiers

PMID39829602
PMCPMC11740623

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.