Evidence map›Paper›PMID 39829538›Full record

ArticleACS omega2025

"Effects of Redox Status on Immediate Hypericin-Mediated Photodynamic Therapy in Human Glioblastoma T98G Cell Line".

Camila Aparecida Errerias Fernandes Cardinali, Camila Fabiano de Freitas, Renato Sonchini Gonçalves, Flavia Amanda Pedroso de Morais, Juliana Nunes de Lima Martins, Yandara Akamine Martins, Jurandir Fernando Comar, Patrícia de Souza Bonfim-Mendonça, André Luiz Tessaro, Elza Kimura and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Targeting glutathione metabolism for tumor radiosensitization (Review).International journal of molecular medicine · 2026
    Review
  2. Method for Isolating Hypericin fromMolecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Camila Aparecida Errerias Fernandes CardinaliDepartament of Physiological Sciences, State University of Maringa, Maringa, Parana 87020-900, Brazil.ORCID https://orcid.org/0000-0001-9666-0430
Camila Fabiano de FreitasDepartment of Chemistry, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina 88040-380, Brazil.ORCID https://orcid.org/0000-0002-9320-8964
Renato Sonchini GonçalvesDepartament of Chemistry, State University of Maringa, Maringa, Parana 87020-900, Brazil.
Flavia Amanda Pedroso de MoraisDepartament of Chemistry, State University of Maringa, Maringa, Parana 87020-900, Brazil.
Juliana Nunes de Lima MartinsDepartament of Biochemistry, State University of Maringa, Maringa, Parana 87020-900, Brazil.
Yandara Akamine MartinsDepartament of Physiological Sciences, State University of Maringa, Maringa, Parana 87020-900, Brazil.ORCID https://orcid.org/0000-0002-4513-7153
Jurandir Fernando ComarDepartament of Biochemistry, State University of Maringa, Maringa, Parana 87020-900, Brazil.
Patrícia de Souza Bonfim-MendonçaDepartment of Clinical Analysis and Biomedicine, State University of Maringa, Maringa, Parana 86812-460, Brazil.
André Luiz TessaroChemistry Graduation (COLIQ), Federal Technological University of Parana, Apucarana, Parana 86800-000, Brazil.
Elza KimuraDepartment of Pharmacy and Pharmacology, State University of Maringa, Maringa, Parana 87020-900, Brazil.
Wilker CaetanoDepartament of Chemistry, State University of Maringa, Maringa, Parana 87020-900, Brazil.
Noboru HiokaDepartament of Chemistry, State University of Maringa, Maringa, Parana 87020-900, Brazil.
Kellen BrunaldiDepartament of Physiological Sciences, State University of Maringa, Maringa, Parana 87020-900, Brazil.ORCID https://orcid.org/0000-0001-9122-1455
Maria Ida RavanelliDepartament of Physiological Sciences, State University of Maringa, Maringa, Parana 87020-900, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma Multiforme (GBM) is one of the most aggressive types of brain tumor. GBM can modulate glutathione (GSH) levels and regulate cellular redox state, which can explain its high resistance to chemotherapeutic agents. Photodynamic therapy (PDT) is a selective, nontoxic, and minimally invasive treatment approved for many types of cancer. PDT leads to cell death mainly by promoting the generation of reactive oxygen species (ROS). Thus, in the current study, PDT with the photosensitizer hypericin (Hyp), formulated in mixed 1,2-dipalmitoyl-

Identifiers

PMID39829538
PMCPMC11740150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.