Evidence map›Paper›PMID 39829510›Full record

ArticleACS omega2025

Global Advancements in Bioactive Material Manufacturing for Drug Delivery: A Comprehensive Study.

Rafael Leandro Fernandes Melo, Dayana Nascimento Dari, Francisco Izaias da Silva Aires, Francisco Simão Neto, Tiago Melo Freire, Bruno Caio Chaves Fernandes, Pierre Basílio Almeida Fechine, João Maria Soares, José Cleiton Sousa Dos Santos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rafael Leandro Fernandes MeloDepartamento de Engenharia Metalúrgica e de Materiais, Universidade Federal do Ceará, Campus do Pici, Bloco 729, Fortaleza CEP 60440-554, CE, Brazil.
Dayana Nascimento DariGrupo de Engenharia e Desenvolvimento Sustentável (GENES), Instituto de Engenharias e Desenvolvimento Sustentável, Universidade da Integração Internacional da Lusofonia Afro-Brasileira, Campus das Auroras, Redenção CEP 62790-970, CE, Brazil.
Francisco Izaias da Silva AiresGrupo de Engenharia e Desenvolvimento Sustentável (GENES), Instituto de Engenharias e Desenvolvimento Sustentável, Universidade da Integração Internacional da Lusofonia Afro-Brasileira, Campus das Auroras, Redenção CEP 62790-970, CE, Brazil.
Francisco Simão NetoDepartamento de Engenharia Química, Universidade Federal do Ceará, Campus do Pici, Bloco 709, Fortaleza 60455-760, CE, Brazil.
Tiago Melo FreireGrupo de Química de Materiais Avançados (GQMat), Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará, Campus do Pici, Fortaleza CEP 60451-970, CE, Brazil.
Bruno Caio Chaves FernandesDepartamento de Agronomia e Ciência Vegetais, Universidade Federal Rural do Semi-Árido, Campus Mossoró, Mossoró CEP 59625-900, RN, Brazil.
Pierre Basílio Almeida FechineGrupo de Química de Materiais Avançados (GQMat), Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará, Campus do Pici, Fortaleza CEP 60451-970, CE, Brazil.ORCID https://orcid.org/0000-0002-7822-2354
João Maria SoaresDepartamento de Física, Universidade do Estado do Rio Grande do Norte, Campus Mossoró, Mossoró CEP 59610-090, RN, Brazil.
José Cleiton Sousa Dos SantosGrupo de Química de Materiais Avançados (GQMat), Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará, Campus do Pici, Fortaleza CEP 60451-970, CE, Brazil.ORCID https://orcid.org/0000-0002-1511-5180

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Manufacturing bioactive materials for drug delivery involves developing materials that interact with biological tissues to release drugs in a controlled and targeted manner. The goal is to optimize therapeutic efficacy and reduce side effects by combining knowledge from materials engineering, biology, and pharmacology. This study presents a detailed bibliometric analysis, exploring the keywords "manufacturing," "bioactive materials," and "drug delivery" to identify and highlight significant advancements in the field. From the Web of Science, 36,504 articles were analyzed, with 171 selected for a deeper analysis, identifying key journals, countries, institutions, and authors. The results highlight the field's interdisciplinary nature, with keywords grouped into four main themes, including regenerative medicine, scaffolds, three-dimensional (3D) printing, bioactive glass, and tissue engineering. Future research in this area will focus on more effective and precise systems using technologies like 3D printing and nanotechnology to enhance the customization and control of drug release, aiming for more efficient and targeted therapies.

Identifiers

PMID39829510
PMCPMC11740136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.