Evidence map›Paper›PMID 39828994›Full record

ArticleACS infectious diseases2025

Discovery of Human PIM Kinase Inhibitors as a Class of Anthelmintic Drugs to Treat Intestinal Nematode Infections.

Victoria Banas, Mostafa A Elfawal, Bruce A Rosa, Matthew Mahoney, Jacquelyn Kauffman, Emily Goetz, Paulina Chen, Raffi V Aroian, Makedonka Mitreva, James W Janetka

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Victoria BanasDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.
Mostafa A ElfawalProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States.
Bruce A RosaDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Matthew MahoneyDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.
Jacquelyn KauffmanDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Emily GoetzProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States.
Paulina ChenProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States.
Raffi V AroianProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, United States.ORCID 0000-0002-9741-3834
Makedonka MitrevaDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
James W JanetkaDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri 63110, United States.ORCID 0000-0002-9888-5411

Funding

Function/optimization of a nematicidal Cry toxin arsenalR01AI056189 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RAFFI V AROIAN · 2005 to 2026
$11.0M
Development of small molecule inhibitors of metabolic enzymes as broad spectrum anthelmintic drugsR01AI159450 · NIAID · WASHINGTON UNIVERSITY · PI JANETKA, JAMES W, MITREVA, MAKEDONKA · 2021 to 2025
$3.9M
Innovative therapeutic strategies to support elimination of river blindnessR01AI174587 · NIAID · WASHINGTON UNIVERSITY · PI James W Janetka, Sara Lustigman · 2023 to 2026
$3.2M
Automated high throughput compound screening for broadly active anti-parasitic nematode drugsR01AI150866 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI AROIAN, RAFFI V · 2020 to 2024
$2.5M
NIAID NIH HHS R01 AI056189NIAID NIH HHS R01 AI150866NIAID NIH HHS R01 AI159450NIAID NIH HHS R01 AI174587
6 · The paper itself

Abstract

Soil-transmitted helminth (STH) infections affect one-fourth of the global population and pose a significant threat to human and animal health, with limited treatment options and emerging drug resistance.

Indexed as

AnthelminticsProtein Kinase InhibitorsProto-Oncogene Proteins c-pim-1TrichurisAncylostomaAnimalsDrug DiscoveryHumansMiceStructure-Activity RelationshipAnthelminticsProtein Kinase InhibitorsProto-Oncogene Proteins c-pim-1anthelminticCX-6258hookwormPIM kinasesoil-transmitted helminthwhipworm

Identifiers

PMID39828994
PMCPMC11995402

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.