SynthesisLasers in medical science2025
Radiographical impact of photobiomodulation therapy on bone regeneration in clinical studies: a systematic review.
Synthesis in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effectiveness of photobiomodulation therapy on bone regeneration of oral and craniofacial defects. A systematic review of animal, and in-vitro studies.Lasers in medical science · 2025Pooled it
- Non-Thermal Plasma vs. Low-Level Laser Therapy for Recurrent Oral Ulcers: A Randomized Controlled Pilot Study.Biomedicines · 2026Article
- Photobiomodulation-pretreated dental follicle stem cells with enhanced osteogenic function improve alveolar bone regeneration.BMC oral health · 2025Article
- The effect of low-level laser therapy after rapid maxillary expansion: Micro-CT analysis.Lasers in medical science · 2025Article
- Efficacy of Three-Dimensional Bioactive Composites in Long Bone Repair with Photobiomodulation.Materials (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone regeneration is a complex process influenced by inflammation and pathological conditions. Efforts to enhance this process include chemical and physical interventions, with PBMT therapy showing promise in improving bone regeneration. Despite conflicting findings in existing literature, this review aims to synthesize clinical evidence on using therapy (PBMT) in bone regeneration and explore its potential clinical applications. A systematic search was performed on electronic databases such as Web of Science, Scopus, and PubMed from the beginning until May 2024 for randomized clinical trials that reported the result of PBMT on bone regeneration. The search strategy involved using a mix of relevant medical subject headings (MeSH) terms and pertinent keywords such as photobiomodulation therapy, low-level laser therapy, bone, regeneration, PBMT, and LLLT. From an initial search identifying 1920 articles, this review centered on 13 articles for analysis, predominantly utilizing radiographical or cone-beam computed tomography (CBCT) assessments. Among these, 7 studies indicated that photobiomodulation therapy (PBMT) did not have a significant impact on bone regeneration. Conversely, 4 studies showed a substantial enhancement in bone density and regeneration with PBMT. Furthermore, 2 studies investigated the impact of varying laser characteristics on case and control groups, concluding no significant difference. In spite of the conflicting results from studies mentioned above, it appears that photobiomodulation has shown positive effects on bone reconstruction. However, further research is necessary to optimize the selection of physical parameters of laser such as wavelength, energy density, and power, as they are crucial for optimizing the effectiveness of photobiomodulation for clinical use.
Indexed as
Identifiers
39828883What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.