ArticleSports medicine (Auckland, N.Z.)2025
Factors Associated with Persisting Post-Concussion Symptoms Among Collegiate Athletes and Military Cadets: Findings from the NCAA-DoD CARE Consortium.
Article in Sports medicine (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Holistic Performance Programming for mTBI Recovery in U.S. Military Tactical Athletes: A Narrative Review.Sports (Basel, Switzerland) · 2026Review
- Existing and Potential Therapies for Post-Traumatic Stress Disorder and Persistent Post-Concussion Symptoms in Intimate Partner Violence: A Narrative Review.Brain sciences · 2026Review
- Incidence, risk factors and outcomes of persistent post-concussion symptoms in Singaporean school-going children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Adverse Childhood Experiences Exacerbate Neurobehavioral and Post-Traumatic Stress Disorder Symptoms Among Survivors of Intimate Partner Violence-Related Head Trauma.Journal of neurotrauma · 2026Article
- Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundPersisting post-concussion symptoms (PPCS) is a condition characterized by prolonged recovery from a mild traumatic brain injury (mTBI) and compromised quality of life. Previous literature, on the basis of small sample sizes, concludes that there are several risk factors for the development of PPCS.
objectiveWe seek to identify protective and risk factors for developing slow recovery or persisting post-concussion symptoms (PPCS) by analyzing medical history, contact sport level, setting, and the Sport Concussion Assessment Tool (SCAT) and Brief Symptom Inventory (BSI-18) assessments at baseline and post-injury. PATIENTS AND
methodsWe studied 47,860 unique collegiate athletes and Military Service Academy (MSA) cadets enrolled in the 30-site National Collegiate Athletic Association and Department of Defense (NCAA-DoD) Concussion Assessment Research and Education (CARE) Consortium prospective cohort study of baseline and post-injury data from 2014 to 2019. Medical histories and preseason baselines (n = 60,720), along with SCAT and BSI-18 examinations (n = 5379) conducted within 48 h post-injury, were analyzed. PPCS is defined as cleared for return to play (RTP) > 29 days.
resultsOf 5073 concussions, the median (95% CI) and mean (SD) RTP were 15.2 (4.8-82.6) days and 22.2 (23.0) days, respectively, with 891 developing PPCS. Sex, high SCAT score, high BSI-18 score, and delayed reporting produced small effect sizes on RTP (d = 0.22-0.44). Adjusted odds ratios (OR) of developing PPCS indicated the following risk factors: SCAT total score > 45 (OR = 1.91, 95% CI: 1.58-2.30), female sex (OR = 1.80, 95% CI: 1.53-2.13), concussion history (OR = 1.80, 95% CI: 1.29-2.52), and delayed reporting (OR = 1.42, 95% CI: 1.20-1.67). In contrast, protective factors against developing PPCS were: being a limited-contact (OR = 0.34, 95% CI: 0.25-0.47), noncontact (OR = 0.35, 95% CI: 0.24-0.51) or contact sport athlete (OR = 0.34, 95% CI: 0.28-0.41); and receiving the concussion at practice (OR = 0.64, 95% CI: 0.53-0.77) or in competition (OR = 0.44, 95% CI: 0.34-0.56). Athletes diagnosed with a learning disability and taking a neurostimulant were more protected than those who were not (OR = 0.44, 95% CI: 0.26-0.76 versus OR = 0.72, 95% CI: 0.49-1.05, respectively). A prognostic model using these variables offers poor sensitivity (9%) but high specificity (98%) in identifying PPCS (AUC = 0.72).
conclusionsThis study of 5073 concussions indicates that female sex, high symptom burden, and prior concussion are risk factors for slow recovery. In addition, learning disability, contact sport, and concussion in competition are protective against slow recovery. The neurostimulant results suggest that clinicians should keep their attention deficit disorder (ADD) and attention-deficit/hyperactivity disorder (ADHD) patients on their current neurostimulant medication after a concussion. A prognostic logistic regression model based on behavioral clinical findings did a poor job of identifying PPCS.
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