Evidence map›Paper›PMID 39828867›Full record

Trial reportJournal of the Egyptian National Cancer Institute2025

A comparative study between central quadrantectomy and nipple resection with areola preservation Versus Grisotti flap mammoplasty in central breast lesions extending to nipple: a randomized clinical trial.

Philobater Bahgat Adly Awad, Basma Hussein Abdelaziz Hassan, Abanoub Adel Shafek Awad, Abdelrahman Ahmed Younis Mohamed Attaia, Kerolos Bahgat Adly Awad, Dina Mohamed Hanafy, Ahmed Gamal El Din Osman

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the Egyptian National Cancer Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Philobater Bahgat Adly Awad *General Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Philobater@med.asu.edu.eg.
Basma Hussein Abdelaziz Hassan *General Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abanoub Adel Shafek AwadGeneral Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abdelrahman Ahmed Younis Mohamed AttaiaGeneral Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Kerolos Bahgat Adly AwadGeneral Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Dina Mohamed HanafyGeneral Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ahmed Gamal El Din OsmanGeneral Surgery Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate central quadrantectomy and nipple resection with areola preservation (CQ-NR-AP) as a new reconstructive oncoplastic technique Versus Grisotti flap mammoplasty (GFM) in central malignant tumors of the breast extending to the nipple, in terms of time procedures, breast symmetry, patient satisfaction, postoperative complications, and local recurrence. PATIENTS AND

methodsThe current study is a single-blind, single-center, randomized, controlled trial that was performed between May 2018 and May 2023 in the breast surgery unit of University Hospitals. This trial involved 40 individuals who had central breast lesions that extended to the nipple and were monitored for two years following surgery.

resultsAs regards the mean intra-operative time in minutes, in the group (I) was 80.1 with a standard deviation of ± 13.9, and ingroup (II) was 138.9 with a standard deviation of ± 14.02 (p = 0.001). The seroma was detected in zero cases in group (I) and 2(10%) cases in group II (p = 0.487) and those two cases were managed by aspiration only. Regarding, the wound infection was found in one case (5%) in group (I) and 3(15%) cases in group II (p = 0.605). Regarding patient satisfaction and breast, symmetry was much better in the group (I).

conclusionThe safety and ease of central quadrantectomy and nipple resection with areola preservation were demonstrated in a two-year follow-up, with a lower incidence of complications compared to the Grisotti flap mammoplasty technique. Furthermore, this approach was associated with higher patient satisfaction, which is a significant achievement in the management of centrally located breast tumors.

trial registrationPACTR202405688323721. 28/05/2024.

Indexed as

Breast NeoplasmsMammaplastyMastectomy, SegmentalNipplesSurgical FlapsAdultFemaleHumansMiddle AgedNeoplasm Recurrence, LocalPatient SatisfactionPostoperative ComplicationsSingle-Blind MethodTreatment OutcomeBreast cancerCentral breast tumorsGrisotti flapGrisotti techniqueMammoplastyOncoplastic breast surgery

Identifiers

PMID39828867
PMCPMC13313456

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.