Evidence map›Paper›PMID 39828634›Full record

ArticleJournal of cellular and molecular medicine2025

Modulation of the Oxygenation State and Intracellular pH of Erythrocytes by Inositol-Trispyrophosphate Investigated by

Sabina Koj, Tomasz Niedziela, Joanna Rossowska, Jean-Louis Schmitt, Jean-Marie Lehn, Claude Nicolau, Claudine Kieda

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sabina KojHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
Tomasz NiedzielaHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
Joanna RossowskaHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
Jean-Louis SchmittISIS-University of Strasbourg, Strasbourg, France.
Jean-Marie LehnISIS-University of Strasbourg, Strasbourg, France.
Claude NicolauNormOxys Inc., Boston, Massachusetts, USA.
Claudine KiedaCentre for Molecular Biophysics, UPR CNRS 4301, Orleans, France.ORCID 0000-0002-7573-029X

Funding

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of SciencesMinistry of Education and Science MIM-NRI 1/9005(520)National Science Centre Poland 2016/23/NZ1/03211National Science Centre Poland 2018/30/E/NZ5/00711National Science Centre Poland 2019/35/B/NZ6/04395
6 · The paper itself

Abstract

The hypoxic microenvironment is crucial for tumour cell growth and invasiveness. Tumour tissue results from adaptation to reduced oxygen availability. Hypoxia first activates pro-angiogenic signals for alleviation. Pathologic, tumour angiogenesis maintains hypoxia, impairing treatment outcomes. Vessel normalisation requires physioxia. Oxygen delivery by red blood cell (RBC) carrying haemoglobin (Hb) is enhanced by myo-inositol trispyrophosphate (ITPP), an effector of oxygen transport by RBCs. Altering glycolytic activity, it lowers intracellular pH and increases oxygen release from Hb.

Indexed as

2,3-DiphosphoglycerateErythrocytesInositol PhosphatesOxygenAnimalsAnion Exchange Protein 1, ErythrocyteHemoglobinsHumansHydrogen-Ion ConcentrationMagnetic Resonance Spectroscopy2,3-DiphosphoglycerateAnion Exchange Protein 1, ErythrocyteHemoglobinsInositol Phosphatesinositol trispyrophosphateOxygen2,3‐diphosphoglycerate31P NMRerythrocytehypoxiamyo‐inositol trispyrophosphateoxygenpH

Identifiers

PMID39828634
PMCPMC11742965

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.