Evidence map›Paper›PMID 39828255›Full record

SynthesisAsia Pacific journal of clinical nutrition2025

Systematic review on supplementation, fortification, and food-based interventions for preventing iron deficiency anemia in low- and middle-income countries.

Siti Helmyati, Lely Lusmilasari, Ayyu Sandhi, Marina Hardiyanti, Gifani Rosilia, Yuliana Novita Rachmawati, Mitha Aristyarini

Abstract readSystematic Review
In one paragraph

Synthesis in Asia Pacific journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siti HelmyatiDepartment of Nutrition and Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. Email: helmyati@ugm.ac.id; siti.helmyati@gmail.com.
Lely LusmilasariCenter for Health and Human Nutrition, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Ayyu SandhiDepartment of Pediatrics and Maternity Nursing, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Marina HardiyantiDepartment of Nutrition and Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Gifani RosiliaCenter for Health and Human Nutrition, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Yuliana Novita RachmawatiCenter for Health and Human Nutrition, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Mitha AristyariniCenter for Health and Human Nutrition, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Funding

Indonesian Danone Institute Foundation & the Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University 956/UN1/FKKMK/KAP/HK/2023
6 · The paper itself

Abstract

BACKGROUND AND

objectivesPrioritizing key preventive and therapeutic interventions is one of the actions to accelerate the reduction of anemia. This study aimed to examine interventions designed to prevent anemia. METHODS AND STUDY

designA systematic search was conducted in PubMed, Web of Science, Scopus, and Cochrane Library. Analysis of publication bias was done using The Joanna-Briggs Institute critical appraisal tool. Data collected from articles included author, year of publication, setting and location of the study, study type, participant of the study, intervention and control given, main outcome, main findings, and risk of bias.

resultsThree nutrition-specific interventions aimed at preventing iron deficiency anemia in low- and middle-income countries used various types and dosages of iron. While most studies showed success, some indicated a worsening trend in anemia, even with standard dosages and the same form of iron. Determining effective interventions requires consideration of factors such as other micronutrient composition, compliance rate, availability of educational intervention, and dietary backgrounds in those countries.

conclusionsSupplementation, fortification, and food-based interventions generally lead to higher hemoglobin levels and a lower prevalence of anemia. However, it is important to consider several factors before deciding on an approach.

Indexed as

Anemia, Iron-DeficiencyDeveloping CountriesDietary SupplementsFood, FortifiedHumansIronIronfortificationironiron deficiency anemiasupplementationvitamin C

Identifiers

PMID39828255
PMCPMC11742596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.