ArticleEnvironmental pollution (Barking, Essex : 1987)2025
Carcinogenic air pollutants and breast cancer risk in the Arkansas rural community health study: A nested case-control study.
Article in Environmental pollution (Barking, Essex : 1987), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relationship Between Climate Change and Breast Cancer and Its Management and Preventative Implications in South Africa.International journal of environmental research and public health · 2025Pooled it
- Statistical approaches to analyse the combined effect of seven air pollutants and breast cancer risk: a case-control study nested in the French E3N-Generations cohort.BMC medicine · 2026Article
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9 authors.
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Abstract
backgroundPrevious epidemiological studies on the associations between hazardous air pollutants (HAPs) and breast cancer (BC) have largely neglected rural, medically underserved areas in the United States, which differ in exposures and disparities compared to urban areas.
objectivesWe aimed to examine the associations between carcinogenic HAPs and BC risk in a rural population.
methodsUsing a nested case-control design, 574 cases and 2295 incidence density-sampled controls matched 1:4 on index age and race were included from the Arkansas Rural Community Health study. Twelve census-tract level HAPs from the 2005 National Air Toxics Assessment were geocoded to participants' baseline addresses and categorized into tertiles based on the control distributions. Multivariable conditional logistic regression analysis was used to estimate associations for BC and subgroups. Additionally, weighted quantile sum (WQS) regression was used to assess the effects of pollutant mixtures.
resultsAdjusted models resulted in significantly increased risk of BC for moderate PAH (OR
conclusionThis study highlights significant associations between specific HAPs, particularly PAHs and chromium, and increased BC risk in a rural population, emphasizing the need for targeted public health interventions and regulatory efforts to mitigate exposure in medically underserved areas.
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