SynthesisContact dermatitis2025
Allergens Responsible for Contact Allergy in Children From 2010 to 2024: A Systematic Review and Meta-Analysis.
Synthesis in Contact dermatitis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- European Society of Contact Dermatitis Guideline for Diagnostic Patch Testing-Recommendations on Best Practice (Update 2026).Contact dermatitis · 2026Guideline
- The Prevalence of Contact Allergy to Formaldehyde and Formaldehyde Releasers: A Systematic Review and Meta-Analysis.Contact dermatitis · 2026Pooled it
- Prevalence of Contact Allergy to Colophonium in Dermatitis Patients: A Systematic Review and Meta-Analysis.Contact dermatitis · 2026Pooled it
- Prevalence of Contact Allergy to Isothiazolinones in Dermatitis Patients From 2000 to 2025: A Systematic Review and Meta-Analysis.Contact dermatitis · 2026Pooled it
- Prevalence of Contact Allergy to Rubber Accelerators From the European Baseline Series in Dermatitis Patients: A Systematic Review and Meta-Analysis.Contact dermatitis · 2025Pooled it
- Prevalence of Contact Allergy to Neomycin in Dermatitis Patients: A Systematic Review and Meta-Analysis.Contact dermatitis · 2025Pooled it
- Contact Sensitisation Trends in Slovenian Children and Adolescents: A Retrospective Single-Centre Study.Contact dermatitis · 2026Article
- A Parade of Persistent and Emerging Contact Allergens - A Clinical Update.Current allergy and asthma reports · 2026Review
- Metal Pollution in the Air and Its Effects on Vulnerable Populations: A Narrative Review.International journal of molecular sciences · 2026Review
- Contact Allergy in Children in Europe: A Proposal for a Paediatric European Baseline Series.Contact dermatitis · 2026Article
- Hair Products Marketed to Adolescents on Social Media: A Cross-Sectional Study.Skin appendage disorders · 2025Article
- What is New in Contact Allergy To Cosmetics for Physicians, Cosmetologists, and Cosmetic Users?Current allergy and asthma reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contact allergy (CA) is a frequent condition in children; however, newer estimates of the prevalence of CA in children are lacking. Herein, we aim to provide an estimate of the prevalence of CA in children from 2010 to 2024. Two authors independently searched PubMed, Embase and Web of Science for studies reporting the prevalence of positive patch tests (PPTs) to allergens in populations including ≥ 100 children (< 18 years). Proportion meta-analyses were conducted to calculate the pooled prevalence estimates of CA in children. Seventeen studies comprising 11 593 children undergoing patch testing with 4176 (36%) PPTs were eligible for inclusion. The allergen with the highest prevalence was nickel (11.9% [95% confidence interval [CI], 8.6%-15.71%]), followed by cobalt (6.6% [95% CI, 4.2%-9.5%]), cocamidopropyl betaine (5.5% [95% CI, 3.1-8.7]), bacitracin (5.2% [95% CI, 1.2%-10.0%]), fragrance mix I (4.8% [95% CI, 2.9%-7.1%]) and methylisothiazolinone (4.3% [95% CI, 2.2%-7.2%]). Children with atopic dermatitis had higher rates of PPTs for cocamidopropyl betaine, propylene glycol, lanolin alcohol and carba mix. Across geographical areas, higher prevalences of several allergens were found in the United States compared to Europe, for example, for methylisothiazolinone. This meta-analysis confirmed that CA is frequent in children across geographical areas; however, differences in the frequency of top allergens depend on regulatory interventions, indicating their value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.