Evidence map›Paper›PMID 39827311›Full record

ArticleScientific reports2025

Exercise induces dynamic changes in intra-articular metabolism and inflammation associated with remodeling of the infrapatellar fat pad in mice.

Timothy M Griffin, Ravi K Komaravolu, Erika Barboza Prado Lopes, Padmaja Mehta-D'souza, Taylor Conner, Tessa Kovats, Susan Kovats, Madeline Allen, Peyton Harris, Mary Beth Humphrey and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Timothy M GriffinAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA. Tim-Griffin@omrf.org.
Ravi K KomaravoluAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA.
Erika Barboza Prado LopesAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA.
Padmaja Mehta-D'souzaAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA.
Taylor ConnerAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA.
Tessa KovatsAging and Metabolism Research Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK, 73104, USA.
Susan KovatsArthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Madeline AllenDepartment of Health and Exercise Science, University of Oklahoma, Norman, OK, 73019, USA.
Peyton HarrisDepartment of Biology, University of Oklahoma, Norman, OK, 73019, USA.
Mary Beth HumphreyVeterans Affairs Medical Center, Oklahoma City, OK, 73104, USA.
Hope D WelhavenDepartment of Chemistry & Biochemistry, Montana State University, Bozeman, MT, 59717, USA.
Priyanka BrahmacharyDepartment of Mechanical & Industrial Engineering, Montana State University, Bozeman, MT, 59717, USA.
Ronald K JuneDepartment of Mechanical & Industrial Engineering, Montana State University, Bozeman, MT, 59717, USA.

Funding

Role of Glucose metabolism in Chondrocyte MechanotransductionR01AR073964 · NIAMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI JUNE, RONALD KENT · 2019 to 2024
$2.4M
Metabolomic Profiling to Identify Candidate Biomarker Profiles and Molecular Endotypes for OsteoarthritisR01AR081489 · NIAMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Ronald Kent June · 2023 to 2026
$1.8M
Biomechanical Regulation of Intra-Articular Adipose Tissue InflammationR03AR066828 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI GRIFFIN, TIMOTHY M · 2014 to 2016
$257k
BLRD VA I01 BX004666BLRD VA I01 BX004882NIAMS NIH HHS R01 AR073964NIAMS NIH HHS R01 AR081489NIAMS NIH HHS R03 AR066828NIH HHS R03AR066828, R01AR073964, R01AR081489U.S. Department of Veterans Affairs I01BX004666, I01BX004882
6 · The paper itself

Abstract

We hypothesized that daily exercise promotes joint health by upregulating anti-inflammatory mediators via adaptive molecular and metabolic changes in the infrapatellar fat pad (IFP). We tested this hypothesis by conducting time-resolved analyses between 1 and 14 days of voluntary wheel running exercise in C57BL/6J mice. IFP structure and cellularity were evaluated by histomorphology, picrosirius red collagen staining, and flow cytometry analysis of stromal vascular fraction cells. Joint inflammation and metabolism were evaluated by multiplex gene expression analysis of synovium-IFP tissue and synovial fluid metabolomics, respectively. Exercise transiently increased cytokine and chemokine gene expression in synovium-IFP tissue, resolving within the first 5 days of exercise. The acute inflammatory response was associated with decreased adipocyte size and elevated CD45

Indexed as

Adipose TissueInflammationPhysical Conditioning, AnimalAdipocytesAnimalsMaleMiceMice, Inbred C57BLSynovial FluidSynovial MembraneAdipocyteFibrosisHoffa’s fat padKneeMetabolomicsMetaflammationRunningSynovium

Identifiers

PMID39827311
PMCPMC11743197

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.