Evidence map›Paper›PMID 39827241›Full record

ArticleNature communications2025

A metal-trap tests and refines blueprints to engineer cellular protein metalation with different elements.

Sophie E Clough, Tessa R Young, Emma Tarrant, Andrew J P Scott, Peter T Chivers, Arthur Glasfeld, Nigel J Robinson

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Microbial metal physiology: ions to ecosystems.Nature reviews. Microbiology · 2025
    Review
  3. Review
  4. Journal of the American Chemical Society · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sophie E Clough *Department of Biosciences, University of Durham, Durham, UK.ORCID http://orcid.org/0000-0003-4044-5197
Tessa R Young *Department of Biosciences, University of Durham, Durham, UK.ORCID http://orcid.org/0000-0002-7373-1969
Emma TarrantDepartment of Biosciences, University of Durham, Durham, UK.
Andrew J P ScottDepartment of Biosciences, University of Durham, Durham, UK.ORCID http://orcid.org/0000-0002-7989-2675
Peter T ChiversDepartment of Biosciences, University of Durham, Durham, UK.ORCID http://orcid.org/0000-0002-8779-1452
Arthur GlasfeldDepartment of Biosciences, University of Durham, Durham, UK.ORCID http://orcid.org/0000-0003-0680-0263
Nigel J RobinsonDepartment of Biosciences, University of Durham, Durham, UK. nigel.robinson@durham.ac.uk.ORCID http://orcid.org/0000-0001-5586-1092

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/S009787/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/V006002/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/W015749/1Research Councils UK (RCUK) MX32736
6 · The paper itself

Abstract

It has been challenging to test how proteins acquire specific metals in cells. The speciation of metalation is thought to depend on the preferences of proteins for different metals competing at intracellular metal-availabilities. This implies mis-metalation may occur if proteins become mis-matched to metal-availabilities in heterologous cells. Here we use a cyanobacterial Mn

Indexed as

AzurinBacterial ProteinsMetalsProtein EngineeringCobaltCopperCyanobacteriaEscherichia coliIronManganeseNickelAzurinBacterial ProteinsCobaltCopperIronManganeseMetalsNickel

Identifiers

PMID39827241
PMCPMC11742986

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.