Evidence map›Paper›PMID 39827226›Full record

ArticleCell death & disease2025

ERG mediates the differentiation of hepatic progenitor cells towards immunosuppressive PDGFRα

Haoran Bai, Xinyu Zhu, Lu Gao, Shiyao Feng, Hegen Li, Xiaoqiang Gu, Jiahua Xu, Chen Zong, Xiaojuan Hou, Xue Yang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Haoran Bai *Department of Oncology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xinyu Zhu *Changhai Clinical Research Unit, Changhai Hospital of Naval Medical University, Shanghai, China.
Lu Gao *National Center for Liver Cancer, Shanghai, China.
Shiyao Feng *Department of Urology, Chaohu Hospital of Anhui Medical University, HeFei, Anhui, China.
Hegen LiDepartment of Oncology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xiaoqiang GuDepartment of Oncology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jiahua XuDepartment of Oncology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chen ZongNational Center for Liver Cancer, Shanghai, China.
Xiaojuan HouNational Center for Liver Cancer, Shanghai, China.
Xue YangNational Center for Liver Cancer, Shanghai, China.
Jinghua JiangNational Center for Liver Cancer, Shanghai, China.
Qiudong ZhaoNational Center for Liver Cancer, Shanghai, China.
Lixin WeiNational Center for Liver Cancer, Shanghai, China.ORCID 0000-0002-9526-5348
Li ZhangChanghai Clinical Research Unit, Changhai Hospital of Naval Medical University, Shanghai, China. lizhangpaper@163.com.
Zhipeng HanDepartment of Oncology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. hanzhipeng0311@126.com.
Wenting LiuNational Center for Liver Cancer, Shanghai, China. liuwenting1015@163.com.
Jianxin QianDepartment of Oncology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. qianjianxin3@163.com.ORCID 0000-0002-0157-1281

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82073032National Natural Science Foundation of China (National Science Foundation of China) 82073037National Natural Science Foundation of China (National Science Foundation of China) 82374532Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 21MC1930500Shanghai Municipal Health Bureau (Shanghai Municipal Public Health Bureau) 20214Y0013
6 · The paper itself

Abstract

Cancer-associated fibroblasts (CAFs) play important roles in the occurrence and development of hepatocellular carcinoma (HCC) and are a key component of the immunosuppressive microenvironment. However, the origin of CAFs has not been fully elucidated. We employed single-cell sequencing technology to identify the dynamic changes in different subsets of fibroblasts at different time points in rat primary HCC model. Inflammation-associated CAFs (Pdgfrα

Indexed as

Cancer-Associated FibroblastsCarcinogenesisCarcinoma, HepatocellularCell DifferentiationLiver NeoplasmsReceptor, Platelet-Derived Growth Factor alphaStem CellsAnimalsHumansMaleRatsTumor MicroenvironmentReceptor, Platelet-Derived Growth Factor alpha

Identifiers

PMID39827226
PMCPMC11743139

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.