Evidence map›Paper›PMID 39827216›Full record

ArticleScientific reports2025

Association between wide-ranging food intake and Parkinson's disease: a comprehensive mendelian randomization study.

Yana Su, Yulei Hao, Wanhui Dong, Ruqing Qiu, Ying Zhang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yana SuDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, 1 Xinmin Street, Changchun City, Jilin Province, China.
Yulei HaoDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, 1 Xinmin Street, Changchun City, Jilin Province, China.
Wanhui DongDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, 1 Xinmin Street, Changchun City, Jilin Province, China.
Ruqing QiuDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, 1 Xinmin Street, Changchun City, Jilin Province, China.
Ying ZhangDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, 1 Xinmin Street, Changchun City, Jilin Province, China. zhang_ying99@jlu.edu.cn.

Funding

Jilin Province Department of Finance Project NO. JLSWSRCZX2020-0011Jilin Province Health and Technology Innovation Project NO.2018J045the Natural Science Foundation of Jilin Province NO. YDZJ202201ZYTS116
6 · The paper itself

Abstract

Parkinson's disease (PD) is a complex neurodegenerative disorder influenced by both genetic and environmental factors, including dietary habits. Despite considerable research, the relationship between food intake and PD risk remains poorly understood. Here, we conducted a comprehensive Mendelian randomization analysis to investigate the association between a wide spectrum of food intake and PD risk. Utilizing data from large-scale genome-wide association studies (GWAS) and dietary databases, we constructed genetic instruments for various dietary factors, including fruit, vegetable, meat, fish, dairy, and grain intake, among others, totaling 170 different food items. Using multivariable inverse variance weighted methods, we found a causal relationship between Mozzarella intake and Parkinson's disease (odds ratio [OR] = 9.83, 95% confidence interval [CI] = 2.52-38.34, P-value < 0.05). Additionally, a causal relationship was observed between Pancake intake and Parkinson's disease (odds ratio [OR] = 0.20, 95% confidence interval [CI] = 0.07-0.59, P-value < 0.05). Furthermore, our reverse Mendelian randomization analysis and multivariable Mendelian randomization analysis provided further support for these findings. To our knowledge, we are the first to investigate the causal relationship between the broad intake of 170 different food items and Parkinson's disease. Our study reveals the causal relationships between Pancake intake, and Mozzarella intake with Parkinson's disease.

Indexed as

DietEatingFeeding BehaviorMendelian Randomization AnalysisParkinson DiseaseGenome-Wide Association StudyHumansOdds RatioPolymorphism, Single NucleotideRisk FactorsDietary habitsFood intakeMendelian randomizationParkinson’s disease

Identifiers

PMID39827216
PMCPMC11742879

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