Evidence map›Paper›PMID 39827215›Full record

ArticleScientific reports2025

TCTEX1D2 is essential for sperm flagellum formation in mice.

Ryua Harima, Kenshiro Hara, Kentaro Tanemura

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ryua HarimaLaboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aoba, Aoba-Ku, Sendai, Miyagi, 980-8572, Japan.
Kenshiro HaraLaboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aoba, Aoba-Ku, Sendai, Miyagi, 980-8572, Japan.
Kentaro TanemuraLaboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki-Aoba, Aoba-Ku, Sendai, Miyagi, 980-8572, Japan. kentaro.tanemura.e4@tohoku.ac.jp.

Funding

Japan Science and Technology Agency JPMJFR2018Japan Science and Technology Agency JPMJSP2114Japan Society for the Promotion of Science 19H01142Japan Society for the Promotion of Science 23K21259
6 · The paper itself

Abstract

Flagella and cilia are widely conserved motile structures, in mammalian, sperm possess flagella. Large protein complexes called dynein, including cytoplasmic dynein 2 and axonemal dynein, play a role in the formation of cilia and flagella. The function of each subunit component of dynein complexes in sperm flagellum formation remains unclear. One such subunit is TCTEX1D2. Co-immunoprecipitation studies showed that TCTEX1D2 interacted with cytoplasmic dynein 2 subunits WDR34, WDR60, and DYNLT1 in the testes. Furthermore, TCTEX1D2 also interacted with WDR63 and WDR78, subunits of inner dynein arm, which is axonemal dynein. Tctex1d2

Indexed as

Sperm TailAnimalsAxonemeCiliaDyneinsFlagellaInfertility, MaleMaleMiceMice, KnockoutSpermatozoaSperm MotilityTestisDyneinsCytoplasmic dynein 2Inner dynein armMale infertilitySpermatogenesisSperm flagellaTCTEX1D2

Identifiers

PMID39827215
PMCPMC11743150

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.