ArticleBMC chemistry2025
Establishment and validation of HPLC methods for the determination of folic acid and parabens antimicrobial agents on folic acid oral solution.
Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Development of a green design reverse phase liquid chromatography method for determining the ionization profile of parabens.RSC advances · 2026Article
- AQbD-assisted HPLC method for simultaneous determination of methylparaben and propylparaben in liquid oral dosage forms.Scientific reports · 2026Article
- Folate-Functionalized ROS-Scavenging Covalent Organic Framework for Oral Targeted Delivery of Ferulic Acid in Ulcerative Colitis.Pharmaceutics · 2025Article
- Electrochemical determination of folic acid in triple-matrix biofluids: a PAni-DES and Au/Printex L6@Chitosan enhanced lab-made screen-printed sensor.Mikrochimica acta · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundAs the common antibacterial drugs in folic acid oral liquid, parabens are listed as mandatory substances in the quality standard. Both the Chinese Pharmacopoeia and the United States Pharmacopoeia use high performance liquid chromatography for the determination of folic acid, but the quantitative methods of parabens are different. Pharmacopoeias use different instruments to quantify folic acid and parabens, resulting in cumbersome and cumbersome detection methods.
objectiveWithout changing the type of instrument and mobile phase, two methods were established for the determination of folic acid and parabens (methyl paraben; ethyl paraben; propyl paraben) using respective wavelengths and flow comparisons Propyl benzoate) high performance liquid chromatography method.
methodChromatographic separation was achieved on an Agilent 5 TC-C
resultsThe method has a good linear relationship with R
conclusionsThe HPLC method was established for the rapid determination of folic acid and antibacterial agent of parabens in folic acid. The method has high accuracy, strong specificity, high recovery rate, good stability and environmental friendliness. Compared with the method in the pharmacopoeia, it has strong resistance to complex matrix interference, greatly shortens the detection time, and has little damage to the instrument and chromatographic column. It can be used for the quality standard of folic acid oral liquid.
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