Evidence map›Paper›PMID 39827090›Full record

ArticleRespiratory research2025

Cortisol regulates neonatal lung development via Smoothened.

Shanshan Lu, Yifei Chen, Jiawen Song, Liangliang Ren, Jun Du, Donglai Shen, Jiayin Peng, Yao Yin, Xia Li, Yuqing Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shanshan Lu *The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Yifei Chen *The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Jiawen Song *State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China.
Liangliang RenThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Jun DuThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Donglai ShenThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Jiayin PengState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China.
Yao YinThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Xia LiThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Yuqing WangThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Yan GaoThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Siman HanThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, 100850, China.
Yichang JiaTsinghua-Peking Joint Center for Life Sciences, School of Medicine, Medical Science Building, Tsinghua University, Beijing, 100084, China.
Yun ZhaoState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China. yunzhao@sibcb.ac.cn.
Yizheng WangNational Clinical Research Center for Aging and Medicine, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, 200040, China. yzwang@ion.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeonatal respiratory distress syndrome (NRDS), one of the main causes of neonatal death, is clinically characterized by progressive dyspnea and cyanosis 1 to 2 h after birth. Corticosteroids are commonly used to prevent NRDS in clinical. However, the protective mechanism of the corticosteroids remains largely unclear.

methodsIn this study, the simulation of the molecular docking by Autodock, in vitro binding experiments, and Sonic Hedgehog (SHH) pathway examination in cells were performed to study the directly binding of cortisol to Smoothened (SMO). To explore the effect of cortisol action on the SHH pathway on neonatal lung development, we generated a genetic mouse, in which leucine 116 (L112 in human) of SMO was mutated to alanine 116 (L116A, Smo

resultsIn this study, we reported that cortisol, the endogenous glucocorticoid, inhibited the sonic hedgehog (Shh)/SMO-mediated proliferation of lung fibroblasts to maintain the normal lung development. Specifically, cortisol competed with cholesterol for binding to the cysteine-rich domain (CRD) in SMO to inhibit the activation of Shh/SMO signaling, a critical signaling known for cell proliferation. Cortisol did not inhibit the activation of SMO when L112 in its CRD was mutated to A112. Moreover, Smo

conclusionTogether, these results suggested that cortisol regulated cholesterol stimulation of SMO by competitively binding to the CRD to regulate neonatal lung maturation in mice.

Indexed as

HydrocortisoneLungSmoothened ReceptorAnimalsAnimals, NewbornHedgehog ProteinsHumansMiceMice, Inbred C57BLMolecular Docking SimulationHedgehog ProteinsHydrocortisoneSmoothened ReceptorSmo protein, mouseCortisolLung developmentNeonatal respiratory distress syndromeSHH pathway

Identifiers

PMID39827090
PMCPMC11743026

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.