Evidence map›Paper›PMID 39827063›Full record

ReviewTrends in pharmacological sciences2025

Advances in the structural understanding of opioid allostery.

Nokomis Ramos-Gonzalez, Balazs R Varga, Susruta Majumdar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in pharmacological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nokomis Ramos-GonzalezDepartment of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St Louis, MO, USA; Center for Clinical Pharmacology, Washington University School of Medicine, St Louis, MO, USA.
Balazs R VargaDepartment of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St Louis, MO, USA; Center for Clinical Pharmacology, Washington University School of Medicine, St Louis, MO, USA.
Susruta MajumdarDepartment of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St Louis, MO, USA; Center for Clinical Pharmacology, Washington University School of Medicine, St Louis, MO, USA. Electronic address: susrutam@wustl.edu.

Funding

Targeting the allosteric sodium site with novel probes for delta opioid receptorR01DA057790 · NIDA · WASHINGTON UNIVERSITY · PI Tao Che, VSEVOLOD KATRITCH · 2023 to 2026
$2.6M
Efficacy and signaling modulation by targeting the sodium site at mu opioid receptorR01DA059978 · NIDA · WASHINGTON UNIVERSITY · PI Susruta Majumdar · 2024 to 2026
$1.8M
NIDA NIH HHS R01 DA057790NIDA NIH HHS R01 DA059978
6 · The paper itself

Abstract

Activation of the μ opioid receptor (MOR) can give analgesia, but also has dangerous side effects. Drugs that target MOR through an allosteric site, meaning they bind outside of the usual pocket, present a novel mode of receptor activation with different pharmacology relative to orthosteric drugs. Recent structural studies give valuable new information on how allosteric modulators interact with MOR.

Indexed as

Analgesics, OpioidReceptors, Opioid, muAllosteric RegulationAllosteric SiteAnimalsHumansAnalgesics, OpioidReceptors, Opioid, muallosterynegative allosteric modulatoropioidpositive allosteric modulatorsodium binding siteμ-opioid receptor

Identifiers

PMID39827063
PMCPMC12001378

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.